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The placenta is one of the most diverse organs among eutherian mammals, and comparative placentation studies can reveal fundamental processes that support a successful pregnancy. A new study in PLOS Biology uses swine placental organoids and in vivo spatial transcriptomics to uncover key insights into placental cell diversity and evolution.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12396701 | PMC |
http://dx.doi.org/10.1371/journal.pbio.3003346 | DOI Listing |
Drug Target Insights
August 2025
Department of Gynecology, Shanghai University of Traditional Chinese Medicine affiliated Shuguang Hospital Anhui Hospital, Anhui, Hefei - China.
Introduction: Bushenhuoxue formula is a traditional Chinese medicine formula with relatively safe clinical effects, but its mechanism in recurrent spontaneous abortion (RSA) is still unclear. Our present study used Network pharmacology an experimental validation to discuss how Bushenhuoxue formula improves prethrombotic state in RSA.
Materials And Methods: The active ingredients of Bushenhuoxue formula (Drug) were acquired from our previous study.
J Matern Fetal Neonatal Med
December 2025
Section of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology and Reproductive Sciences, Yale School of Medicine, New Haven, Connecticut, USA.
Objective: To evaluate the association between low-volume chorionic villus sampling (CVS) and delay in patient care.
Methods: This is a retrospective cohort study of patients who underwent CVS from 8/19/2019 to 12/31/2022 in a single center. The exposure was low-volume CVS, defined as less than 15 mg of sample.
J Obstet Gynaecol
December 2025
Maternal and Foetal Medicine Unit, University Hospitals of Leicester NHS Trust, Leicester, UK.
Background: Maternal obesity is a growing global health concern, yet its impact on maternal haemodynamic throughout pregnancy remains underexplored. We investigated haemodynamic adaptations across gestation in women with high body mass index (BMI) (≥35 kg/m) and results were compared to low-risk controls (BMI 18.5-24.
View Article and Find Full Text PDFJ Med Virol
September 2025
Laboratory of Dermatology and Immunodeficiencies, Department of Dermatology, University of São Paulo Medical School, São Paulo, Brazil.
Mother-to-child transmission (MTCT) is the primary route of human T-lymphotropic virus type 1 (HTLV-1) infection. Although formula feeding reduces breastfeeding-associated transmission, MTCT still occurs, implicating pregnancy or delivery as key transmission windows. In this study, placental tissues from nine HTLV-1-positive mothers were analyzed using DNA/RNAscope, revealing low HTLV-1 DNA and RNA levels and a low RNA/DNA ratio, consistent with latent infection in the placenta and potentially explaining the low MTCT rate.
View Article and Find Full Text PDFMol Med Rep
November 2025
Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK.
Asprosin is glucogenic adipokine that exerts a wide repertoire of actions, including the regulation of appetite, insulin resistance and cell proliferation. At present, little is known about the actions of asprosin in the human placenta. The present study investigated the effects of asprosin on the transcriptome of the BeWo and JEG‑3 placental cell lines, and assessed the expression of FBN1/Furin and asprosin's candidate receptors in healthy placentas when compared against placentas from pregnancies where the carrier had gestational diabetes mellitus (GDM).
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