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Traditionally, walnuts have occupied an imperative position in the functional food market with consistently recognized nutritious and functional properties. In the past years, the lipid profile of walnuts has brought much scientific attention via linking a cascade of biological attributes and health-promoting effects. Over time, researchers have focused on diversified composition (polyphenols and vitamins) of different parts of walnut (flower, pellicle, and kernel) and emphasized their physiological significance. Consequently, a plethora of reports has emerged on the potential role of walnut consumption against a series of diseases including cancer, gut dysbiosis, cardiovascular, and neurodegenerative diseases. Therefore, we accumulated the updated data on composition and classification, extraction methods, and utilization of different parts of walnuts as well as associated beneficial effects under in vivo and clinical studies. Altogether, this review summarized the ameliorative effects of a walnut-enriched diet in chronic diseases which can be designated to the synergistic or individual effects of walnut components mainly through anti-oxidative and anti-inflammatory role.
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http://dx.doi.org/10.1080/10408398.2021.1881439 | DOI Listing |
Phytomedicine
August 2025
College of Food Science and Technology, Yunnan Agricultural University, Kunming 650201, China; Yunnan Provincial Key Laboratory of Precision Nutrition and Personalized Food Manufacturing, Yunnan Agricultural University, Kunming 650201, China; Yunnan Provincial Engineering Research Center for Edible
Background: Walnut septum, a Juglans regia L. by-product with culinary-medicinal value, is a rich source of bioactive polyphenols. The chemical complexity and anti-colitis activities of these polyphenols remain uncharacterized.
View Article and Find Full Text PDFClin Nutr
August 2025
The Health & Nutrition Innovative International Research Center, Faculty of Health Sciences, Ben-Gurion University of the Negev, David Ben-Gurion Blvd. 1, Beer-Sheva, 8410501, Israel; Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG), Helmholtz Zentrum München, University of
Background And Aims: We explored whether changes in serum proteomic profiles differed between participants with distinct brain aging trajectories, and whether these changes were influenced by dietary intervention.
Methods: In this secondary analysis of the 18-month DIRECT PLUS trial, 294 participants were randomized to one of three arms: 1) Healthy dietary guidelines (HDG); 2) Mediterranean (MED) diet (+440 mg/day polyphenols from walnuts); or 3) low red/processed meat green-MED diet (+1240 mg/day polyphenols from walnuts, Mankai plant, and green tea). We measured 87 serum proteins (Olink-CVDII).
Sci Rep
August 2025
Faculty of Agricultural Sciences and Technology, Department of Field Crops, Sivas University of Science and Technology, Sivas, Türkiye.
Common walnut (Juglans regia L.) is a globally important nut crop valued for its nutritional and economic benefits. Despite Türkiye's importance as a walnut producer, molecular characterization of local genotypes, particularly from historically cultivated regions such as inner Anatolia remains limited.
View Article and Find Full Text PDFJ Asian Nat Prod Res
August 2025
Ministry of Education + Traditional Chinese medicine (TCM) biological genetics (Heilongjiang Province Double First-class Construction Interdiscipline), Ministry of Education, Key Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Harbin 150040,
Two new compounds () and thirteen known tetrahydroaphcosterones () were isolated from the green walnut husks of , with structures elucidated via spectroscopic analyses. Cytotoxicity screening against BGC-823, A-549, and HepG-2 cancer cell lines revealed that compound inhibited A-549 with the IC value of (54.94 ± 1.
View Article and Find Full Text PDFJ Am Coll Surg
August 2025
Department of Surgery, Division of General Surgery, University of Toronto, Toronto, ON, Canada.
Background: Tissue-based inguinal hernia repairs (IHRs), such as the Shouldice technique, are an acceptable alternative to mesh-based repairs in appropriately selected patients; however, they are often thought to be more painful than tension free repairs in the early postoperative period. We aimed to compare short-term pain and quality of life (QoL) between the Shouldice and Lichtenstein techniques for IHR.
Methods: The Abdominal Core Health Quality Collaborative (ACHQC) database was queried for patients who underwent open IHR between January 2017 and April 2023.