Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Thirty years of research have revealed the fundamental role of the ubiquitin-proteasome system in diverse aspects of cellular regulation in eukaryotes. The ubiquitin-protein ligases or E3s are central to the ubiquitin-proteasome system since they determine the specificity of ubiquitylation. The cullin-RING ligases (CRLs) constitute one large class of E3s that can be subdivided based on the cullin isoform and the substrate adapter. SCF complexes, composed of CUL1 and the SKP1/F-box protein substrate adapter, are perhaps the best characterized in plants. More recently, accumulating evidence has demonstrated the essential roles of CRL3 E3s, consisting of a CUL3 protein and a BTB/POZ substrate adaptor. In this Review, we describe the variety of CRL3s functioning in plants and the wide range of processes that they regulate. Furthermore, we illustrate how different classes of E3s may cooperate to regulate specific pathways or processes.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8932378 | PMC |
| http://dx.doi.org/10.1038/s41477-020-00833-6 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Serum heat shock protein family A member 9 protein as a biomarker for bortezomib resistance and poor prognosis in patients with multiple myeloma.
Anticancer Drugs
September 2025
Department of Blood and Marrow Transplantation, Tianjin Cancer Hospital Airport Hospital, National Clinical Research Center for Cancer.
Bortezomib resistance in multiple myeloma (MM) is a significant clinical challenge that limits the long-term effectiveness. Currently, there is a lack of reliable biomarkers to predict bortezomib resistance. Previous studies reported that several proteins regulate bortezomib resistance through targeting ubiquitin-proteasome pathways, including heat shock protein family A member 9 (HSPA9), dickkopf Wnt signaling pathway inhibitor 1 (DKK1), proteasome 26S subunit non-ATPase 14 (PSMD14), and tripartite motif containing 21 (TRIM21).
View Article and Find Full Text PDFMolecular mechanism of Tralopyril-induced enteritis in Pacific oyster (Crassostrea gigas) through multi-pathway modulation: Network toxicology and experimental validation.
Pestic Biochem Physiol
November 2025
Marine College, Shandong University, Weihai, Shandong 264209, China. Electronic address:
Tralopyril (TP), a representative bromopyrrolonitrile, functions as a broad-spectrum insecticide, raising growing concerns about its potential impact on aquatic organisms and human intestinal health. However, the key targets and toxicity mechanisms underlying TP-induced enteritis remain unclear. In this study, we utilized network toxicology combined with molecular docking to comprehensively explore the potential molecular mechanisms underlying TP-induced enteritis.
View Article and Find Full Text PDFGenome-wide investigation and functional analysis of 20S proteasome subunits in Locusta migratoria.
Pestic Biochem Physiol
November 2025
Key Laboratory of Zoological Systematics and Application of Hebei Province, College of Life Sciences, Hebei University, Baoding, China. Electronic address:
The 20S proteasome is a core component of the ubiquitin-proteasome system, participating in various biological processes such as cell cycle regulation, signal transduction, apoptosis, and protein homeostasis. However, its roles in mammals are well-documented, its function in the insect intestine remains largely unexplored. In this study, we identified 14 20S proteasome subunits, including 7 α-subunits and 7 β-subunits in Locusta migratoria, a worldwide agricultural pest.
View Article and Find Full Text PDFTargeted degradation of hexokinase 2 by a novel engineered bispecific chimeric liposome-based Nano-PROTACs for enhancing tumor chemotherapy.
Biomaterials
August 2025
Institute of Medical Research, Northwestern Polytechnical University, Xi'an, Shaanxi, 710072, China; Research & Development Institute of Northwestern Polytechnical University in Shenzhen, Guangdong, 518057, China. Electronic address:
Aerobic glycolysis is critical for tumor development and metastasis. Regulating the activity of vital metabolic enzymes in the tumor glycolysis process, such as hexokinase 2 (HK-2), is expected for tumor treatment. However, conventional small molecule inhibitors only block the activity of proteases with consistently high doses via occupation-driven pattern, leading to off-target effects which limit their clinical application.
View Article and Find Full Text PDFPROTACs Targeting Molecular Targets in Triple-Negative Breast Cancer.
Curr Med Chem
August 2025
Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Prem Nagar, Dehradun, 248007, Uttarakhand, India.
Triple-Negative Breast Cancer (TNBC) is defined as a type of breast cancer having the absence of estrogen, progesterone, and human epidermal growth factor receptors. So far, chemotherapeutic drugs and immunotherapy have several issues, such as being resistant to treatment, being harmful to the body, and not being fully effective. Lately, PROTACs have been discovered to assist in the breakdown of difficult-to-target oncoproteins employing the ubiquitin-proteasome system.
View Article and Find Full Text PDF