Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Purpose: The purpose of this study was to investigate the usefulness of ultrafast MRI with conventional dynamic contrast-enhanced (DCE)-MRI for predicting histologic upgrade of ductal carcinoma in situ (DCIS) to invasive cancer.
Methods: This retrospective study enrolled 53 biopsy-proven DCIS lesions in 53 patients and divided into two groups based on postoperative histopathologic diagnoses: non-upgrade and upgrade to invasive cancer groups. Imaging features of conventional DCE-MRI and ultrafast MRI, and histopathologic features were reviewed and compared between the two groups. Interobserver agreements for MRI features were analyzed by two radiologists. The radiologic and histopathologic parameters for predicting histologic upgrade of DCIS were identified using multiple linear regression.
Results: Seventeen lesions (32.1 %) were histologically upgraded to invasive cancer after surgery. The interobserver agreement for ultrafast MRI parameters was excellent, and maximum slope (MS) and maximum enhancement (ME) showed the highest reliability (intraclass correlation coefficients, 0.907 and 0.897, respectively). The upgrade group showed significantly larger lesion size on MRI (median 40 mm [25 to 75 percentiles 16.0-83.0] vs. 18.5 mm [10.0-29.8], p < 0.001), higher MS (12.1 %/s [8.2-13.9] vs. 8.7 %/s [6.4-11.1], p = 0.004), and higher ME (236.5 % [153.7-253.7] vs. 175.4 % [140.1-207.7], p = 0.027) than non-upgrade group. Lesion size (≥ 20 mm), MS (> 11.5 %), and ME (> 229.1 %) were significant predictors for histologic upgrade, which could predict 10 cases of histologic upgrade (10/17, 58.8 %) without a false-positive case.
Conclusion: Preoperative ultrafast MRI with conventional DCE-MRI could be useful in management decisions for DCIS patients.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.ejrad.2020.109519 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Evaluating breast lesions with ultrafast DCE-MRI: The impact of temporal resolution on pharmacokinetics.
Magn Reson Imaging
September 2025
Department of Radiology, Fudan University Shanghai Cancer Center, Shanghai, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China. Electronic address:
Objective: This study aimed to evaluate the impact of temporal resolution on pharmacokinetic parameters and the performance in diagnosing breast cancer.
Methods: This prospective study included 89 consecutive patients with 97 lesions (76 malignant and 21 benign). Ultrafast dynamic contrast-enhanced (UF-DCE) imaging was performed on a 3-T MRI scanner using CAIPIRINHA-Dixon-TWIST-VIBE (CDTV) with a native temporal resolution of 4.
Development of a prediction model for HER2 low breast cancer using quantitative intra- and peri-tumoral heterogeneity and MRI features on high-spatial resolution ultrafast DCE-MRI.
Quant Imaging Med Surg
September 2025
Department of Radiology, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, University of Electronic Science and Technology of China, Chengdu, China.
Background: Accurate preoperative human epidermal growth factor receptor 2 (HER2) status assessment is crucial for guiding treatment selection, particularly with the emergence of anti-HER2 antibody-drug conjugates (ADCs) for HER2-low breast cancer. However, current immunohistochemistry (IHC)-based classification is limited by spatial heterogeneity and sampling bias. Quantitative analysis of intra- and peri-tumoral heterogeneity (ITH) on imaging may offer a non-invasive, objective, and reproducible approach to distinguish HER2-low breast cancer from other subtypes.
View Article and Find Full Text PDFObjective: Quantitative magnetic resonance imaging (qMRI) has attracted more and more attention in clinical diagnosis and medical sciences due to its capability to non-invasively characterize tissue properties. Nevertheless, most qMRI methods are time-consuming and sensitive to motion, making them inadequate for quantifying organs with physiological movement. In this context, single-shot multiple overlapping-echo detachment (MOLED) imaging technique has been presented, but its acquisition efficiency and image quality are limited when the field of view (FOV) is smaller than the object, especially for abdominal organs and myocardium.
View Article and Find Full Text PDFNeonatal neuroimaging: from research to bedside practice.
Semin Perinatol
August 2025
Willem-Alexander Children's Hospital, Department of Pediatrics, Division of Neonatology, Leiden University Medical Center, the Netherlands.
Neonatal neuroimaging is essential in research and clinical practice, offering important insights into brain development and neurologic injury mechanisms. Visualizing the brain enables researchers and clinicians to improve neonatal care and parental counselling through better diagnosis and prognostication of disease. Common neuroimaging modalities used in the neonatal intensive care unit (NICU) are cranial ultrasonography (cUS) and magnetic resonance imaging (MRI).
View Article and Find Full Text PDFImproving real-time ultrasound spine imaging with a large-aperture array.
Sci Adv
July 2025
Department of Radiology, Stanford University, Palo Alto, CA, USA.
Ultrasound offers a safe, low-cost alternative to computed tomography (CT) and magnetic resonance imaging for spinal diagnostics and intervention by enabling real-time imaging. However, the complex structure of the spine and acoustic shadowing from bones present challenges for ultrasonography. This study addresses these limitations using an 8.
View Article and Find Full Text PDF