Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
A decarboxylative protocol has been developed toward a range of carbocycles. The key success is based on the use of a batch of newly designed cyclic carbonates as substrates that can provide carbon-carbon zwitterion intermediate under palladium catalysis. The kinetics of the reactions are controllable toward either strained seven- or thermodynamically more favored five-membered carbocycles. The release of this chemistry will shed light on the synthesis of complex and valuable cyclic structures.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/acs.orglett.0c03856 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
A machine learning approach to concussive group classification using discrete outcome measures from a low-cost movement-based assessment system.
Med Eng Phys
October 2025
University of Missouri, Department of Physical Therapy, Columbia, MO, USA. Electronic address:
Measurable neuromotor control deficits during functional task performance could provide objective criteria to aid in concussion diagnosis. However, many tools which measure these constructs are unidimensional and not clinically feasible. The purpose of this study was to assess the classification accuracy of a machine learning model using features measured by a clinically feasible movement-based assessment system (Mizzou Point-of-care Assessment System (MPASS) between athletes with and without concussion.
View Article and Find Full Text PDFEstablishing clinically relevant dissolution specifications for prodrug bioequivalence risk assessment: Integration of a dissolution/permeation system with physiologically based biopharmaceutics modeling in abiraterone acetate.
Eur J Pharm Biopharm
September 2025
Center of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing 210009, China. Electronic address:
Prodrugs with enzymatic activation requirements, such as the weakly basic biopharmaceutical classification system (BCS) class IV compound abiraterone acetate (ABA), face considerable bioequivalence (BE) risks owing to their pH-dependent solubility, food effects, and variable intestinal hydrolysis. This study established clinically relevant dissolution specifications for ABA using biorelevant dissolution and physiologically based biopharmaceutics modelling (PBBM). Two dissolution methods, two-stage (gastrointestinal transfer simulation) and single-phase (biorelevant media), were evaluated under fasted and fed conditions.
View Article and Find Full Text PDFImpact of wettability heterogeneity on methane hydrate growth kinetics in partially water-saturated sediments.
J Colloid Interface Sci
August 2025
Research Centre of Ecology & Environment for Coastal Area and Deep Sea, Guangdong University of Technology, Guangzhou 510006, China; Guangdong Basic Research Center of Excellence for Ecological Security and Green Development, Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou),
Hypothesis: Gas hydrate formation in sediments is influenced by the availability of gas-water interfacial areas, which governs gas-water interactions. The surface wettability of sediment particles is expected to affect the spatial distribution of water within the pore space, thereby altering the extent of gas-liquid contact. Consequently, by tuning the wettability heterogeneity of the sediment, the spatial distribution of pore water can be regulated, which in turn influences the gas-water interactions and the kinetics of gas hydrate formation.
View Article and Find Full Text PDFBioinspired DNA Framework-Programmed Heteroligation for Affinity-Enhanced Biodetection.
Small Methods
September 2025
Institute of Molecular Medicine, Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China.
Natural polyreactive antibodies achieve enhanced avidity through heterogeneous ligand binding. However, engineering synthetic heteroligation systems with precise control over recognition motif orientation and distance remains challenging. Here, a DNA framework-based strategy is presented to program heterotypic binding by spatially organizing bivalent aptamers targeting platelet-derived growth factor-BB (PDGF-BB).
View Article and Find Full Text PDFIncreased Fibroblast-Like Synoviocyte Inflammation in Rheumatoid Arthritis Revealed by Sphingosine 1-Phosphate Receptor 1-Targeting PET/CT Imaging.
Mol Pharm
September 2025
Guangdong Provincial Engineering Research Center of Molecular Imaging, The Fifth Affiliated Hospital, Sun Yat-Sen University, Zhuhai, Guangdong 519000, China.
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by joint inflammation. This study aimed to use the sphingosine 1-phosphate receptor 1 (S1PR1) targeted tracer [F]TZ4877 with PET/CT to assess synovial inflammation in a collagen-induced arthritis (CIA) mouse model. [F]TZ4877 and [F]FDG PET/CT imaging were performed on RA ( = 6) and control ( = 6) mice.
View Article and Find Full Text PDF