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Pasireotide improves hypercortisolemia and induces hyperglycemia via somatostatin receptor type-5 stimulation. GLP-1RA and SGLT2 inhibitor potentially help regulate hyperglycemia in patients with Cushing's disease, especially after pasireotide administration.
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http://dx.doi.org/10.1002/ccr3.3230 | DOI Listing |
J Endocrinol Invest
September 2025
Department of Medicine-DIMED, University of Padova, Padova, Italy.
Background: Cushing's syndrome (CS) is associated with increased metabolic and cardiovascular (CV) risk factors and morbidities. Evidence-based guidelines for the management of these issues in active or remitted CS are not available, so best practice is derived from guidelines developed for the general population. We aimed to evaluate the awareness and practice variation for CV comorbidities of CS across Reference Centres (RCs) of the European Reference Network on Rare Endocrine Conditions (Endo-ERN).
View Article and Find Full Text PDFClin Chim Acta
September 2025
Pain Management Center, Hospital Angeles Mocel, Mexico City, Mexico.
Glucose metabolism alterations are frequently observed in patients with secretory pituitary adenomas. The most commonly secreted hormones in these tumors include prolactin, growth hormone (GH), adrenocorticotropic hormone (ACTH), and thyroid-stimulating hormone (TSH), all of which can disrupt glucose homeostasis through distinct pathophysiological mechanisms. Prolactin stimulates pancreatic β-cell proliferation, enhances insulin gene transcription, increases intracellular insulin content, and augments glucose-induced insulin secretion.
View Article and Find Full Text PDFEndocrine
September 2025
Gray Faculty of Medical & Health Sciences, Tel Aviv University, Tel Aviv, Israel.
Front Vet Sci
August 2025
Department of Animal Medicine, Faculty of Veterinary Medicine, Aswan University, Aswan, Egypt.
Introduction: Obesity is a significant risk factor that predisposes horses to laminitis, equine metabolic syndrome, arthritis, heart disease, and respiratory issues.
Methods: Mares showing overweight or laminitis ( = 30), different BCS ( = 90) weighing 350-550 Kg were subjected to clinical and rump fat assessments. Blood samples were collected to measure circulating estradiol, progesterone, cortisol, insulin, insulin-like growth factor-1 (IGF-1), and leptin.
J Neurol Surg B Skull Base
October 2025
Department of Neurosurgery, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, Arizona, United States.
Objectives: Patients undergoing surgery for Cushing's disease may be more likely to be readmitted to the hospital than other patients with pituitary disorders. We investigated rates, causes, and predictors of unplanned readmission following transsphenoidal surgery for Cushing's disease to identify areas for clinical, financial, and administrative improvements.
Design: Retrospective cohort study.