An evaluation of the efficacy of ethanolic extract of L. () on the clinical parameters of moderate‑to‑severe gingivitis: A split‑mouth clinical study.

Introduction: Gingivitis is a relatively innocuous and reversible inflammation of gingiva. If left untreated, it might progress involving the deeper supporting periodontal tissues of the tooth with consequent mobility and tooth loss. Compelling literature has suggested the role of local antibacterial and anti‑inflammatory agents as an adjunct to scaling and root planing (gold standard) for treating periodontal diseases. Various herbs such as ( A. Juss), ( (L.) P.J.H. Hurter & Mabb.) and turmeric (a L.) have been used for gingivitis since ancient times. L. () is one such herb known for its remarkable anti‑inflammatory, antioxidant and antimicrobial properties and thus has been utilized in the present study.

Aim: The aim of the study was to explore the clinical efficacy of different ethanolic solutions of in moderate‑to‑severe gingivitis patients.

Materials And Methods: It is a split‑mouth clinical study with 24 patients of moderate‑to‑severe gingivitis from the age group of 25-45 years. Recruited individuals were divided in to group I, group II and group III (scaling and root planning i.e., control) and group I, group II and group III (experimental). Three doses of solution 1 (1:3), solution 2 (1:1) and solution 3 (3:1) were administered to the experimental groups for 3 consecutive days. The clinical parameters, i.e., gingival index (GI) and plaque index (PI) were recorded at baseline, 14 days and 28 days in all the individuals. ANOVA test was used in the study for statistical analysis.

Results: Intergroup comparison in terms of GI showed statistically significant difference at 14 and 28 day from baseline between II at only 28 day between II & II and insignificant difference between III & III at all time intervals from baseline. On intragroup comparison, statistically significant reduction in GI in all groups from baseline till 28 days was found, but among experimental groups best result was seen in group III ( < 0.001; F value 153.75). As far as PI is concerned, intergroup comparison between different groups displayed statistically significant difference from baseline to 14 and 28 day between all groups i.e I& I, II& II and III& III. On intragroup comparison, statistically significant reduction in PI in all control groups i.e I II & III was found, but among experimental groups only group III provided statistically significant reduction ( < 0.001, F value 30.40).

Conclusion: The results of this study indicate that, the ethanolic extract of is effective in the treatment of moderate to severe gingivitis.