Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Background: The prognostic importance of intraparotid lymph node metastasis (P+) in patients with primary parotid gland carcinoma is unclear.
Methods: Nineteen retrospective and noncomparative cohort studies, published between 1992 and 2020, met the inclusion criteria and included 2202 patients for this systematic review.
Results: The pooled prevalence of the P in adult patients in the unselected studies was 24.10% (95% confidence interval = 17.95-30.25). The number of P+ lymph nodes per patient was counted in only three studies and ranged from 1 to 11. The 5-year recurrence-free survival rate based on Kaplan-Meier analysis varied from 83% to 88% in P- patients compared to 36% to 54% in P+ patients. The average hazard ratio for tumor recurrence in patients with P+ compared to P- was 2.67 ± 0.58.
Conclusions: P+ is an independent negative prognostic factor in primary parotid gland cancer and should be included into the treatment planning.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/hed.26541 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Parotitis: An approach for general practitioners.
Aust J Gen Pract
September 2025
MBChB (Hons), FRCS (ORL-HNS),@FRACS (OHNS), Consultant Head@and Neck/Ears, Nose and Throat Surgeon,@Department of Otolaryngology, Sunshine Coast@University Hospital, Sunshine Coast, Qld.
Background: Parotitis, inflammation of the parotid glands, is a clinically significant presentation with a wide range of aetiologies that can result in systemically unwell patients.
Objective: The aim of this article is to: (1) outline the assessment of parotitis and distinguish features relevant to determining the aetiology; (2) discuss the role of imaging in parotitis and other serological tests; (3) provide treatment principles and management approaches in treating parotitis in the general practice setting; and (4) identify key features that necessitate referral to an ear, nose and throat service or escalation in treatment.
Discussion: When encountering parotitis in the primary care setting, a comprehensive history and examination is necessary to evaluate the patient, direct further ancillary investigations and to plan treatment.
Nasopharyngeal cancer adaptive radiotherapy with CBCT-derived synthetic CT: deep learning-based auto-segmentation precision and dose calculation consistency on a C-Arm linac.
Radiat Oncol
August 2025
Technology Development Department, Anhui Wisdom Technology Co.,Ltd, Hefei, China.
Background: To evaluate the precision of automated segmentation facilitated by deep learning (DL) and dose calculation in adaptive radiotherapy (ART) for nasopharyngeal cancer (NPC), leveraging synthetic CT (sCT) images derived from cone-beam CT (CBCT) scans on a conventional C-arm linac.
Materials And Methods: Sixteen NPC patients undergoing a two-phase offline ART were analyzed retrospectively. The initial (pCT) and adaptive (pCT) CT scans served as gold standard alongside weekly acquired CBCT scans.
Primary temporal bone osteosarcoma presenting as a parotid tumor: A case report with diagnostic challenges.
Radiol Case Rep
October 2025
Department of Diagnostic and Interventional Radiology, Kochi Medical School, Kochi University, Kochi, Japan.
Osteosarcoma rarely arises from the temporal bone, and few primary cases have been reported in adults. The prognosis of head and neck osteosarcoma is generally poor because of the complex anatomy in the region. Complete resection with negative margins is essential to adequately treat head and neck osteosarcoma.
View Article and Find Full Text PDFImpact of daily adaptive head and neck radiotherapy on toxicity and quality-of-life: results of the DARTBOARD phase II randomized trial.
J Natl Cancer Inst
August 2025
Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Background: The utility of adaptive radiotherapy (ART) for head and neck squamous cell carcinoma (HNSCC) remains poorly defined. Daily ART (DART) promises both anatomic adaptation and planning target volume (PTV) reduction. In this prospective trial using cone-beam computed tomography-based ART, patients with HNSCC undergoing definitive radiotherapy (RT) or chemoradiotherapy (CRT) were randomized to DART with reduced PTV margins or no ART with standard margins (image-guided RT [IGRT]).
View Article and Find Full Text PDFIndividualization of clinical target volume delineation in eccentric nasopharyngeal carcinoma: a prospective comparative study.
Front Oncol
August 2025
Radiation Oncology Center, Chongqing University Cancer Hospital, School of Medicine, Chongqing University, Chongqing, China.
Background: Clinical target volume (CTV) delineation is a major focus in radiotherapy for nasopharyngeal carcinoma (NPC) and currently lacks a universally accepted standard across treatment centers. We proposed an individualized CTV delineation method for eccentric NPC and evaluated its feasibility based on the eccentric distance of the primary lesion.
Materials And Methods: Ninety patients with eccentric NPC were included.