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We have developed a cyanide-free strategy for the synthesis of glycosyl carboxylic acids, which can provide 1,2- or 1,2- glycosyl carboxylic acids and is compatible with common protecting groups. The synthetic utility was demonstrated by the synthesis of 12 unreported glycosyl acids and the total synthesis of scleropentaside A.
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http://dx.doi.org/10.1021/acs.orglett.0c02949 | DOI Listing |
Biochem Soc Trans
August 2025
Department of Molecular and Structural Biochemistry, North Carolina State University, Raleigh, NC, 27695, U.S.A.
Congenital disorders of glycosylation are a significant underlying cause of developmental and epileptic encephalopathy (DEE). A subset of these DEE cases results from biallelic variants in the unique, essential gene encoding UDP-glucose dehydrogenase (UGDH). The UGDH enzyme catalyzes two successive NAD+- dependent oxidation reactions to convert the C6 hydroxyl of UDP-glucose to a carboxylate, generating the UDP-glucuronate product.
View Article and Find Full Text PDFXi Bao Yu Fen Zi Mian Yi Xue Za Zhi
August 2025
Discipline of Chinese and Western Integrative Medicine, Jiangxi University of Traditional Chinese Medicine, Integrated Chinese and Western Medicine Institute for Children Health & Drug Innovation, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China. *Corresponding authors, E-m
Objective Through integrative bioinformatics analysis of multi-source transcriptomic data, potential biomarkers to asthma epithelial cells were identified. The expression of these candidate target was subsequently validated in lung tissues and epithelial cells from asthma models. Methods The gene expression profile data of epithelial cells from three asthma patient cohorts and corresponding healthy controls were integrated from the Gene Expression Omnibus (GEO) database.
View Article and Find Full Text PDFMolecules
June 2025
Division of Science, Institute for Radiation Sciences, The University of Osaka, 1-1 Machikaneyama, Toyonaka 560-0043, Osaka, Japan.
Peptidoglycan (PGN) is a component of bacterial cell walls; its fragments are recognized by the cytoplasmic receptors Nod1 and Nod2, thereby promoting the production of inflammatory cytokines and antibodies. To further elucidate these biological defense mechanisms, a large and stable supply of the PGN fragments via chemical synthesis is essential. However, the synthesis and purification of long PGN fragments are quite challenging due to their low solubility.
View Article and Find Full Text PDFJ Org Chem
July 2025
Key Laboratory of Material Chemistry for Energy Conversion and Storage, Ministry of Education, Hubei Key Laboratory of Bioinorganic Chemistry and Materia Medica, School of Chemistry & Chemical Engineering, Huazhong University of Science & Technology, Luoyu Road 1037, Wuhan 430074, P. R. China.
Although previous studies have shown that per-benzoylated/acetylated 1--(methylthio)thiocarbonyl glycoses are highly reactive glycosyl donors with unique advantages, their synthesis and purification remain challenging, which were successfully addressed in this study. Through the investigation of the product distribution of these donors, two types of side products, β-1--(methylthio)carbonyl glycoses and 2--(methylthio)thiocarbonyl, α-1--carboxylate glycoses, were identified as the result of 1,2-acyl migration of acylated glycosyl hemiacetal. Based on this, we have developed an efficient and generalized method for the synthesis of various disarmed (alkylthio)carbonyl glycose donors, which are typically mixtures of major α-1--(alkylthio)thiocarbonyl glycoses and minor β-1--(alkylthio)carbonyl glycoses when 1,2-acyl migration on the sugar ring occurs readily.
View Article and Find Full Text PDFRespir Res
July 2025
Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA.
Background: Pulmonary emphysema occurs frequently in older adults, often without airflow limitation. Its presence predicts symptoms, respiratory hospitalizations and deaths, and all-cause mortality. Proteomics may provide further insights into emphysema pathogenesis and inform therapeutic targets.
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