[Analysis of internal exposure levels of manganese, cobalt, selenium and molybdenum in blood and urine among general population in parts of Shaanxi Province].

Objective: To investigate the internal exposure levels of manganese(Mn), cobalt(Co), selenium(Se) and molybdenum(Mo) in blood and urine among the general population in parts of Shaanxi Province, and thereby to analyze their population distribution characteristics.

Methods: In 2017, a total of 720 subjects of general people aged 3-79 years were recruited from 5 counties in Shaanxi Province, by stratified random sampling method, blood and urine samples were collected, and the contents of Mn, Co, Se and Mo in blood and urine samples were detected by inductively coupled plasma mass spectrometry(ICP-MS). The test result were statistically analyzed according to different genders, regions and age groups.

Results: Among general people in Shaanxi Province, the median of Mn in blood and urine were separately 8. 43 and 0. 60 μg/L. The median of Mn in blood among males and females were 7. 99 and 8. 81 μg/L, the difference was statistically significant(P<0. 05), the difference of blood Mn between urban and rural areas was statistically significant(P<0. 05). The median of Co in blood and urine were separately 0. 13 and 0. 17 μg/L, the median of Co in blood among males and females were 0. 12 and 0. 15 μg/L, the median of Co in urine among males and females were 0. 16 and 0. 20 μg/L, the differences were statistically significant(P<0. 05), the differences of blood Co and urine Co in urban and rural areas were statistically significant(P<0. 05). The median of Se concentration in blood and urine were separately 73. 20 and 13. 30 μg/L, the median of Se in urine among males and females were 14. 40 and 12. 40 μg/L, the difference were statistically significant(P<0. 05), the differences of blood Se and urine Se in urban and rural areas were statistically significant(P<0. 05). The median of Mo concentration in blood and urine were separately 0. 60 and 50. 40 μg/L, the median of Mo in urine among males and females were 56. 60 and 43. 00 μg/L, the difference was statistically significant(P<0. 05), the difference of blood Mo between urban and rural areas was statistically significant(P<0. 05). Within the same gender, all indexes in whole blood(except female blood Se) were statistically significant among age groups(P<0. 05). The differences of male urine Co, urine Se, urine Mo and female urine Co among age groups were statistically significant(P<0. 05).

Conclusion: Among general population in Shaanxi Province, the Mn, Co, Se and Mo levels in blood and urine are varied by gender age and area, the blood Se level is relatively low.