Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/mds.28336 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
A human striatal-midbrain assembloid model of alpha-synuclein propagation.
Brain
September 2025
Okinawa Institute of Science and Technology Graduate University, Okinawa, 904-0495, Japan.
Animal models of the pathology of Parkinson's disease (PD) have provided most of the treatments to date, but the disease is restricted to human patients. In vitro models using human pluripotent stem cells (hPSCs)-derived neural organoids have provided improved access to study PD etiology. This study established a method to generate human striatal-midbrain assembloids (hSMAs) from hPSCs for modeling alpha-synuclein (α-syn) propagation and recapitulating basal ganglia circuits, including nigrostriatal and striatonigral pathways.
View Article and Find Full Text PDFDynamic brain network reconfiguration following rTMS in males with cocaine use disorder.
Front Hum Neurosci
August 2025
School of Biomedical Engineering, Harbin Institute of Technology (Shenzhen), Shenzhen, China.
Cocaine use disorder (CUD) is characterized by cortico-striatal circuit dysregulation and high relapse rates, with repetitive transcranial magnetic stimulation (rTMS) emerging as a potential neuromodulatory intervention. This study investigates rTMS-induced dynamic brain network reconfigurations in 30 CUD patients using longitudinal resting-state fMRI from the SUDMEX-TMS cohort. Applying Leading Eigenvector Dynamics Analysis (LEiDA) to phase-locking states, we identified four metastable network configurations mapped to canonical resting-state networks.
View Article and Find Full Text PDFTargeting KCNN4 channels modulates microglial activation and apoptosis in a PD-relevant inflammatory model.
Biomed Pharmacother
September 2025
Department and Graduate Institute of Pharmacology, College of Pharmacy, National Defense Medical University, Taipei, Taiwan; Department of Pharmacy Practice, Tri-Service General Hospital, National Defense Medical University, Taipei, Taiwan; School of Pharmacy, College of Pharmacy, National Defense M
Parkinson's disease (PD) is characterized by chronic neuroinflammation and progressive dopaminergic neurodegeneration, driven primarily by the activation of microglia and associated apoptotic pathways. The intermediate-conductance calcium-activated potassium channel KCNN4 has recently emerged as a potential therapeutic target, yet its role in chronic neurodegenerative conditions remains underexplored. In this study, we investigated whether pharmacological inhibition of KCNN4 using TRAM-34 can modulate both inflammatory and apoptotic responses in an LPS-induced mouse model of PD.
View Article and Find Full Text PDFThe end-stage pathology of Parkinson's disease (PD) involves the loss of dopamine-producing neurons in the substantia nigra pars compacta (SNc). However, synaptic deregulation of these neurons begins much earlier. Understanding the mechanisms behind synaptic deficits is crucial for early therapeutic intervention, yet these remain largely unknown.
View Article and Find Full Text PDFCharacteristics of the 18F-fluorodeoxyglucose (F-FDG) and [F] 9-fluoropropyl-(+)-dihydrotetrabenazine (F-FP-DTBZ) positron emission tomography (PET) in patients with cognitive impairment in Parkinson's disease.
Clin Radiol
July 2025
Department of Radiology and Nuclear Medicine, Xuanwu Hospital, Capital Medical University, Beijing 100053, China; Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Beijing, China; Key Laboratory of Neurodegenerative Diseases, Ministry of Education, Beijing, China. Electroni
Aim: Mild cognitive impairment (MCI) is common in Parkinson's disease (PD). This study compared cerebral metabolism and dopaminergic function in PD patients with MCI (PD-MCI) versus those with normal cognition (PD-NC) and healthy controls (HC).
Material And Methods: A total of 78 PD patients (40 PD-MCI, 38 PD-NC) and 28 HC underwent 18F-fluorodeoxyglucose positron emission tomography (F-FDG PET) (metabolism) and [F] 9-fluoropropyl-(+)-dihydrotetrabenazine (F-FP-DTBZ) PET (dopaminergic vesicular transporter).