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Article Abstract
Aim: Mild cognitive impairment (MCI) is common in Parkinson's disease (PD). This study compared cerebral metabolism and dopaminergic function in PD patients with MCI (PD-MCI) versus those with normal cognition (PD-NC) and healthy controls (HC).
Material And Methods: A total of 78 PD patients (40 PD-MCI, 38 PD-NC) and 28 HC underwent 18F-fluorodeoxyglucose positron emission tomography (F-FDG PET) (metabolism) and [F] 9-fluoropropyl-(+)-dihydrotetrabenazine (F-FP-DTBZ) PET (dopaminergic vesicular transporter). Group comparisons used t-tests. Correlations between PET measures and cognitive scores (MMSE, MoCA) were assessed.
Results: PD-MCI patients showed significantly reduced FDG uptake in frontal and parietal regions compared to PD-NC (P=0.003, P=0.025). PD-MCI also exhibited lower F-FP-DTBZ binding, particularly in bilateral caudate (contralateral P=0.018; ipsilateral P=0.048). In PD patients, FDG uptake in frontal/parietal lobes and F-FP-DTBZ uptake in caudate and putamen positively correlated with MMSE and MoCA scores (all P<0.05).
Conclusion: Striatal dopamine depletion and hypometabolism in frontal/parietal regions are associated with cognitive deficits in PD-MCI patients.
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| http://dx.doi.org/10.1016/j.crad.2025.107038 | DOI Listing |
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