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| http://dx.doi.org/10.1016/j.jvir.2020.07.002 | DOI Listing |
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Improved Etiological Diagnosis of Nonresolving or Slowly Resolving Pneumonia Through Combined Endobronchial Ultrasound-Guided Biopsy and Metagenomic Sequencing.
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Department of Respiratory and Critical Care Medicine, The Affiliated Dazu's Hospital of Chongqing Medical University, Chongqing, China.
Nonresolving or slowly resolving pneumonia (NRP) poses a diagnostic challenge because infectious and noninfectious etiologies often mimic community-acquired pneumonia on imaging. Endobronchial ultrasound-guided transbronchial lung biopsy (EBUS-TBLB) improves tissue acquisition for peripheral lesions, whereas metagenomic next-generation sequencing (mNGS) offers culture-independent pathogen detection. Whether their combination enhances etiological clarification of NRP remains uncertain.
View Article and Find Full Text PDFHow Does the Diagnostic Effectiveness of Transbronchial Needle Aspiration/Transbronchial Biopsy With Radial Endobronchial Ultrasound for the Diagnosis of Peripheral Pulmonary Lesions Differ With and Without a Guide Sheath?
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Department of Respiratory Medicine, Nagoya University Graduate School of Medicine.
Background: The diagnostic yield of virtual bronchoscopy with radial endobronchial ultrasound (r-EBUS) for peripheral pulmonary lesions (PPLs) remains unsatisfactory because of limited lesion access by biopsy instruments. r-EBUS-guided transbronchial needle aspiration (TBNA) followed by transbronchial biopsy (TBB) (TBNA/TBB) with a guide sheath (GS) potentially increases the PPL diagnostic yield as the needle penetrates the bronchial wall, enabling subsequent forceps biopsy closer to the lesion. However, regarding the application of r-EBUS-guided TBNA/TBB for PPL diagnosis, data on the diagnostic yield of TBNA/TBB with a GS are limited compared with those on TBNA/TBB without a GS.
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Unit of Diagnostic Imaging and Interventional Radiology, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy.
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Single-walled carbon nanotubes hitchhike on Ly-6C monocytes for photoacoustic image-guided photothermal shock therapy of metabolic inflammation.
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Metabolic inflammation (metaflammation) may occur throughout the body and evolve into various metabolic syndromes, so developing a universal approach for diagnosing and treating metaflammation is meaningful. Here, we developed a single-walled carbon nanotube (SWNT)-based photothermal shock therapy (PTST) for photoacoustic image-guided therapy of metaflammation. Mechanistically, SWNTs are specifically taken up by Ly-6C monocytes in peripheral blood and then rerouted to inflamed tissues Ly-6C monocyte hitchhiking.
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