Establishing consensus recommendations for metastatic hormone-sensitive prostate cancer in South Korea: A modified Delphi study.

Purpose: Consensus is lacking among South Korean urologists on the appropriate treatment of metastatic hormone-sensitive prostate cancer (mHSPC). A modified, Delphi-based consensus on managing mHSPC patients was developed to support clinical decision-making.

Materials And Methods: Thirty-six questions on mHSPC treatment were developed by an expert committee (five urologists).

Enhancement of inter-/intra-reader agreement using the Prostate Imaging Reporting and Data System version 2.1 for prostate cancer detection in magnetic resonance imaging/transrectal ultrasound software fusion prostate biopsy.

Purpose: This study evaluated inter-/intra-reader agreement with the Prostate Imaging Reporting and Data System (PI-RADS) version 2.1 to improve the detection rate of prostate cancer.

Materials And Methods: We enrolled 210 patients who underwent multiparametric magnetic resonance imaging (mpMRI) for clinically suspected or diagnosed prostate cancer.

Development of a Prediction Model for Acute Exacerbation in Idiopathic Pulmonary Fibrosis: A Study of the Korea IPF Cohort Registry.

Background: Acute exacerbation (AE) of idiopathic pulmonary fibrosis (IPF) has the most disastrous impact on prognosis as a major cause of morbidity and mortality. However, there is no proven treatment, and the occurrence of AE is unpredictable. This study aimed to develop a prediction model for AE in patients with IPF using the nationwide Korea IPF Cohort (KICO) registry.

EGFL7 Inhibits the Immune Response in Metastatic Castration-Resistant Prostate Cancer by Deactivating Endothelial Intercellular Adhesion Molecule-1.

Purpose: Epidermal growth factor-like 7 (EGFL7) has been implicated in various cancers, but its role in different stages of prostate cancer (PCa), particularly metastatic castration-resistant prostate cancer (mCRPC), remains unclear. This study aimed to investigate the biological function of EGFL7 and its association with immune regulation in PCa.

Materials And Methods: We quantified EGFL7 and intercellular adhesion molecule-1 (ICAM-1) levels in serum and prostate tissue specimens from patients with benign prostatic hyperplasia (BPH), localized PCa, and mCRPC.

Establishment of a Depression Model Using Dexamethasone-treated Three-dimensional Cultured Rat Cortical Cells.

Objective: models are useful for exploring the molecular mechanisms underlying impaired neuroplasticity in depression. In this study, we developed a three-dimensional spheroid model in which we investigated the effects of the synthetic glucocorticoid dexamethasone on key pathways involved in neuroplasticity, specifically BDNF, sirtuin 1, and mTORC1 signaling.

Methods: A micro-spheroid device was fabricated using photolithography and soft lithography, and cortical spheroids were generated from primary rat cortical cells.

A randomized, active-controlled, multicenter, phase 3 clinical trial to evaluate the efficacy and safety of GV1001 in patients with benign prostatic hyperplasia.

Objectives: To determine and compare the efficacy and safety of GV1001 and 5 mg finasteride for benign prostatic hyperplasia (BPH) patients.

Patients And Methods: This randomized, active-controlled, multicenter, phase 3 clinical trial enrolled 423 patients aged ≥50 years with a prostate volume (PV) >30 mL. Patients were randomized into Group 1 (GV1001 0.

SRT2104 enhances dendritic outgrowth and spine formation through Sirtuin 1-mediated mTORC1 signaling.

Impaired neuroplasticity is a one of the key pathological mechanism of depression. Sirtuin 1 plays a crucial role in neuroplasticity; however, its precise mechanisms remain unclear. This study examined whether sirtuin 1 regulates dendritic outgrowth and spine formation via mTORC1 signaling in rat primary cortical cells under dexamethasone-induced neurotoxic conditions.

The impact of a bacterial lysate on composition of the lung microbiota in a mouse model of asthma exposed to titanium dioxide as one of air pollutants.

Environmental microbes have been linked to both beneficial and harmful effects on the lungs in relation to asthma. The aim of our study was to characterize the bacterial microbiome in lung samples from a mouse model of asthma exposed to titanium dioxide (TiO2) particles, and the effect of OM-85 Broncho-Vaxom®, a bacterial lysate on lung microbiome in mice. The mice were divided randomly into four groups of 6-8 mice per group.

Technological advances in visualizing and rewiring microtubules during plant development.

Microtubules are crucial regulators of plant development and are organized by a suite of microtubule-associated proteins (MAPs) that can rapidly remodel the array in response to varied cues. This complexity has inspired countless studies into microtubule function from the subcellular to tissue scale, revealing an ever-increasing number of microtubule-dependent processes. Developing a comprehensive understanding of how local microtubule configuration, dynamicity, and remodeling drive developmental progression requires new approaches to capture and alter microtubule behavior.

Korean Guidelines for Diagnosis and Management of Interstitial Lung Diseases.

Interstitial lung disease (ILD) comprises a heterogeneous group of disorders characterized by interstitial compartment proliferation, inflammatory infiltration, and potential fibrosis with abnormal collagen deposition. Diagnosis requires a multidisciplinary consensus integrating clinical, radiological, and pathological findings. Idiopathic interstitial pneumonia (IIP) includes idiopathic pulmonary fibrosis (IPF), idiopathic nonspecific interstitial pneumonia (NSIP), desquamative interstitial pneumonia (DIP), acute interstitial pneumonia (AIP), and respiratory bronchiolitis-ILD (RB-ILD), each exhibiting distinct prognostic and therapeutic implications.

Association of MYH10 with clinical variables in obstructive lung diseases.

https://bit.ly/4dFsSGH.

Effects of tianeptine on mTORC1-mediated neuronal autophagy in primary rat hippocampal neurons under nutrient deprivation.

The aim of this study was to investigate the effects of the antidepressant tianeptine on the mechanistic target of rapamycin complex 1(mTORC1)-mediated autophagy pathway in primary hippocampal neurons exposed to B27-deprived conditions. When primary hippocampal neurons were treated with tianeptine at doses of 1, 10, 50, and 100 µM for 3 days under B27-deprived conditions, we observed that it activated autophagy and increased the formation of autophagosomes through the upregulation of autophagic proteins, including autophagy-activating kinase 1 (ULK1), Beclin 1, LC3B-II/I, and p62. And at a concentration of 100 µM tianeptine, the decrease in mTORC1 phosphorylation induced by B27 deprivation was significantly reversed.

Development of an Alginate Gel Composite with Antibacterial Properties Capable of Binding Calcium-Based Residual Stone Fragments in Endoscopic Stone Surgery.

Complete removal of urinary stones remains a challenge, as residual fragments can contribute to recurrence and postoperative urinary tract infections. This study presents an initial laboratory investigation into the development of an alginate gel composite designed to bind calcium-based stone remnants and exhibit antibacterial properties. To evaluate gel formation, calcium oxalate powder reagent and sodium alginate (SA) powder reagent were mixed in a Becker glass and stirred on a hot plate.

Flexural Behavior of Thin Concrete Slabs Reinforced with Surface Embossed Grid-Type Carbon-Fiber Composites.

Fiber-reinforced polymers (FRPs) are being increasingly used to replace rebars as reinforcements for concrete. In this study, the flexural behavior of one-way concrete slabs reinforced with a grid-type carbon FRP (CFRP) (carbon grid), in the form of strands with embossed surfaces, was experimentally investigated. The experimental variables included the effective depth, number of carbon grid layers, and concrete compressive strength.

Tensile Behavior Assessment of Grid-Type CFRP Textile-Reinforced Mortar with Different Design Variables.

This study investigates the tensile behavior of carbon-fiber-reinforced polymer (CFRP) and textile-reinforced mortar (TRM) under various design variables to enhance understanding and application in construction structures. TRM reinforced with CFRP grids is highly effective for strengthening existing structures due to its lightweight nature, durability, ease of installation, and corrosion resistance. The research aims to evaluate how design parameters such as the CFRP grid type, mortar matrix strength (influenced by the water-to-cement ratio), specimen length, and grid width affect TRM's mechanical properties.

Evaluation of the Flexural Behavior of One-Way Slabs by the Amount of Carbon Grid Manufactured by Adhesive Bonding.

Fiber-reinforced polymers (FRPs), which are resistant to corrosion, are used as reinforcement material for concrete. However, the flexural behavior of concrete members reinforced with FRPs can vary depending on the properties of FRPs. In this study, the flexural behavior of one-way concrete slab specimens reinforced with a new grid-type carbon-fiber-reinforced polymer (CFRP) (carbon grid) manufactured by bonding pultruded CFRP strands to an adhesive was investigated.

Expression of G2019S LRRK2 in Rat Primary Astrocytes Mediates Neurotoxicity and Alters the Dopamine Synthesis Pathway in N27 Cells via Astrocytic Proinflammatory Cytokines and Neurotrophic Factors.

Astrocytes in the brain contribute to various essential functions, including maintenance of the neuronal framework, survival, communication, metabolic processes, and neurotransmitter levels. Leucine-rich repeat kinase 2 (LRRK2) is associated with the pathogenesis of Parkinson's disease (PD). LRRK2 is expressed in neurons, microglia, and astrocytes and plays diverse roles in these cell types.

Proportion of Non-Medical Opioid Use of Prescription Opioids among Cancer Patients in Korea.

Purpose: Limited research has been conducted on the prevalence of non-medical opioid use (NMOU) in Korean cancer patients who have received prescription opioids (PO). This study aimed to identify the potential proportion of NMOU in cancer patients who had been prescribed opioids in Korea.

Methods: A retrospective cohort analysis was conducted on 14,728 patients who underwent cancer-related treatment between January 2009 and December 2019, using electronically collected data from a tertiary hospital in Korea.