Refining Indications for Orbital Floor Reconstruction in Zygomaticomaxillary Complex Fractures.

Purpose: Zygomaticomaxillary complex (ZMC) fractures are common, accounting for ∼40% of all facial fractures. Given the integral component the ZMC plays in the formation of the orbit, all fractures to the ZMC entail some degree of injury to the orbital floor itself. Standard treatment involves open reduction and internal fixation, but the necessity of orbital floor exploration in these cases remains debated.

Impact of barbed suture use in complex back closure on operative time, cost, and safety profile.

Objective: Complex locoregional closure of back wounds following spine surgery via muscle flap closure, as opposed to traditional layer-by-layer approximation, decreases rates of complications such as seroma, infection, and dehiscence. However, the impact of barbed suture use on operative time, surgical cost, and patient outcomes for these cases remains unknown. In this study, the authors aimed to evaluate the complication profile, time, and cost savings of barbed suture in complex flap closure of back wounds following the placement of spinal instrumentation.

Inhibition of the Caveolin-1 pathway promotes apoptosis and overcomes pan-tyrosine kinase inhibitor resistance in hepatocellular carcinoma.

Resistance to multi-tyrosine kinase inhibitors (TKI) is a major clinical concern in advanced hepatocellular carcinoma (HCC). Herein, we aimed to uncover the mechanisms underlying pan-TKI resistance and to identify potential therapeutic targets. We used multiple TKI-resistant HCC cell lines to identify caveolin-1 (CAV1) as a key driver of therapeutic resistance.

Contribution of perineuronal nets to hyperexcitability in pilocarpine-induced status epilepticus.

Objective: Changes in extracellular matrix (ECM) and highly condensed ECM structures called perineuronal nets (PNNs) have been reported in human patients with epilepsy as well as some animal models of epilepsy. We studied potential ECM changes in a mouse model of pilocarpine-induced status epilepticus (PISE) and their potential contributions to seizures.

Methods: We used a reduced intensity pilocarpine model to induce status epilepticus (SE) in mice.

Functional Features of Senescent Cells and Implications for Therapy.

Cellular senescence is a key mechanism of aging. Senescent cells negatively affect the function of tissues and organs, significantly contributimg to the aging of the organism. Functional and structural characteristics of senescent cells, such as genomic changes and cell cycle arrest, lysosome and mitochondrial dysfunction, and production of SASP factors, are promising therapeutic targets in the context of healthy longevity.