Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Background: A closed-loop system of insulin delivery (also called an artificial pancreas) may improve glycemic outcomes in children with type 1 diabetes.
Methods: In a 16-week, multicenter, randomized, open-label, parallel-group trial, we assigned, in a 3:1 ratio, children 6 to 13 years of age who had type 1 diabetes to receive treatment with the use of either a closed-loop system of insulin delivery (closed-loop group) or a sensor-augmented insulin pump (control group). The primary outcome was the percentage of time that the glucose level was in the target range of 70 to 180 mg per deciliter, as measured by continuous glucose monitoring.
Results: A total of 101 children underwent randomization (78 to the closed-loop group and 23 to the control group); the glycated hemoglobin levels at baseline ranged from 5.7 to 10.1%. The mean (±SD) percentage of time that the glucose level was in the target range of 70 to 180 mg per deciliter increased from 53±17% at baseline to 67±10% (the mean over 16 weeks of treatment) in the closed-loop group and from 51±16% to 55±13% in the control group (mean adjusted difference, 11 percentage points [equivalent to 2.6 hours per day]; 95% confidence interval, 7 to 14; P<0.001). In both groups, the median percentage of time that the glucose level was below 70 mg per deciliter was low (1.6% in the closed-loop group and 1.8% in the control group). In the closed-loop group, the median percentage of time that the system was in the closed-loop mode was 93% (interquartile range, 91 to 95). No episodes of diabetic ketoacidosis or severe hypoglycemia occurred in either group.
Conclusions: In this 16-week trial involving children with type 1 diabetes, the glucose level was in the target range for a greater percentage of time with the use of a closed-loop system than with the use of a sensor-augmented insulin pump. (Funded by Tandem Diabetes Care and the National Institute of Diabetes and Digestive and Kidney Diseases; ClinicalTrials.gov number, NCT03844789.).
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7920146 | PMC |
| http://dx.doi.org/10.1056/NEJMoa2004736 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Artificial Intelligence for Management of Major Depression: Initial Design, Progress, and Research Plans.
Alpha Psychiatry
August 2025
Information Sciences and Technology, George Mason University, Fairfax, VA 22030, USA.
Background: Herein, we report on the initial development, progress, and future plans for an autonomous artificial intelligence (AI) system designed to manage major depressive disorder (MDD). The system is a web-based, patient-facing conversational AI that collects medical history, provides presumed diagnosis, recommends treatment, and coordinates care for patients with MDD.
Methods: The system includes seven components, five of which are complete and two are in development.
Inverting the Rhodamine Paradigm: Closed-Form Fluorescence with 280 nm Stokes Shift Drives Plastic Circularity.
Angew Chem Int Ed Engl
September 2025
Shaanxi Key Laboratory of New Concept Sensors and Molecular Materials, Key Laboratory of Applied Surface and Colloids Chemistry, Department of Chemistry and Chemical Engineering, ShaanXi Normal University, Xi'an, 710062, P.R. China.
Rhodamine derivatives exhibiting inverted open-closed form fluorescence behavior redefines conventional photochemical paradigms while illuminating new structure-property relationships and fascinating application potentials. Herein, we report a donor-acceptor engineering strategy that activates closed form emission in rhodamines, achieving unprecedented Stokes shifts (>280 nm) while overcoming aggregation-caused quenching. The new class of rhodamines with inverted open-close form emission behavior are created through simultaneous substitution of N,N-diethyl groups with indole (donor) and conversion of spiro-lactam to benzene sulfonamide (acceptor).
View Article and Find Full Text PDFHazards in the port system and their impact on safety performance: an empirical study of the hazard management system of the Tianjin Port Group.
Int J Occup Saf Ergon
September 2025
College of Safety Science and Engineering, Civil Aviation University of China, China.
This study investigates how sustained governance of hidden hazards influences safety performance in port systems, using data from 54 production and key non-production enterprises within the Tianjin Port Group. Employing correlation analysis, regression modeling and mediation-moderation analysis, the study finds that both systematic hazard governance and standardized safety management significantly improve safety outcomes. Basic management-level governance directly reduces the frequency of incidents, while site-level governance enhances safety performance indirectly by promoting standardization.
View Article and Find Full Text PDFBiogas slurry impregnation-driven hydrothermal synthesis of artificial humic acid: Mechanistic insights and agricultural implications.
Bioresour Technol
September 2025
College of Engineering, Huazhong Agricultural University, Wuhan 430070, China. Electronic address:
In response to the challenges of nutrient limitations and low efficiency in synthesizing artificial humic acid (AHA) during the resource utilization of agricultural wastes, this study innovatively developed a process that integrates biogas slurry (BS) impregnation pretreatment with hydrothermal humification (HTH). Using steam-exploded corn straw (SES) as the raw material, the impregnation parameters were optimized (40 °C, liquid-to-solid ratio of 15:1, 18 h, 3 cycles), achieving an AHA yield of 40.61 %, which was over 15 % higher than that of the untreated group.
View Article and Find Full Text PDF[Effect analysis of innovative model on perioperative pain management in prostate cancer patients with hematuria undergoing prostatic artery embolization].
Zhonghua Nan Ke Xue
August 2025
Department of Interventional Therapy, General Hospital of Eastern Theater Command, Nanjing, Jiangsu 210002, China.
Objective: To investigate the effect of innovative perioperative pain management on prostate cancer patients with hematuria undergoing prostatic artery embolization (PAE).
Methods: A total of 60 patients undergoing PAE in the Interventional Therapy Department of General Hospital of Eastern Theater Command from May 2024 to January 2025 were selected by convenience sampling method and randomly divided into the intervention group and the control group, with 30 patients in each group. The control group received traditional pain management of nursing.