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A balanced detector system with a high signal-to-noise ratio (SNR) is the key technology for 2 μm coherent wind lidar, which can enhance the ability for the digital receiver to detect extremely weak signals. The photodiode is the main detection component of a balanced detector system. The variance of junction capacitance of different photodiodes will cause the degradation of SNR. Based on the linear relationship between the junction capacitance of a photodiode and the reverse voltage in the double logarithmic coordinates, a balanced detector system is designed to have the ability to adjust the reverse voltage by using the external digital-to-analog converter. An optimization of the circuit performance can be achieved by adjusting the junction capacitance, which significantly affects the circuit noise and signal bandwidth in the design of the high bandwidth transimpedance amplifier, which is sensitive to parasitic capacitance and component error. A simplified optical system is built to test the performance of the designed balanced detector system. The results show that the SNR of the detector system is ∼10% higher than that of the commercial product, which can further increase the detection distance of the wind lidar by ∼1.5 km for the detection limit of 10 km.
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http://dx.doi.org/10.1063/1.5144829 | DOI Listing |
Med Phys
September 2025
Department of Radiology, Stony Brook University, New York, USA.
Background: In contrast-enhanced digital mammography (CEDM) and contrast-enhanced digital breast tomosynthesis (CEDBT), low-energy (LE) and high-energy (HE) images are acquired after injection of iodine contrast agent. Weighted subtraction is then applied to generate dual-energy (DE) images, where normal breast tissues are suppressed, leaving iodinated objects enhanced. Currently, clinical systems employ a dual-shot (DS) method, where LE and HE images are acquired with two separate exposures.
View Article and Find Full Text PDFEur J Pharm Biopharm
September 2025
RaDes GmbH, Schnackenburgallee 114, 22525 Hamburg, Germany. Electronic address:
Polysorbate 20 (PS20) is one of the most commonly used non-ionic surfactants in cosmetics, pharmaceuticals and food products. Considered as biocompatible and non-irritating, it is further valued for its solubilising and protein stabilising properties. PS20 is manufactured through a multi-stage reaction of sorbitol with various fatty acids and ethylene oxide, resulting in a complex mixture of components with different molecular weights and polarity.
View Article and Find Full Text PDFAppl Radiat Isot
September 2025
Kahramanmaraş İstiklal University, Department of Energy Systems Engineering, Kahramanmaraş, Türkiye.
The rapid advancement of three-dimensional (3D) printing technologies has significantly expanded their potential applications such as sensors and detector technology. In this study, the gamma-ray shielding performance of ulexite-doped composite resins fabricated via Digital Light Processing (DLP) 3D printing was experimentally investigated to evaluate radiation attenuation capacity. Composite resins containing different ulexite loadings (0, 1, 3, and 5 wt%) were exposed to gamma rays at energies of 356, 662, 1173, and 1333 keV to evaluate their attenuation characteristics.
View Article and Find Full Text PDFJ Med Imaging (Bellingham)
September 2025
Otto von Guericke University, Institute for Medical Engineering and Research Campus STIMULATE, Magdeburg, Germany.
Purpose: The combination of multi-layer flat panel detector (FPDT) X-ray imaging and physics-based material decomposition algorithms allows for the removal of anatomical structures. However, the reliability of these algorithms may be compromised by unaccounted materials or scattered radiation.
Approach: We investigated the two-material decomposition performance of a multi-layer FPDT in the context of 2D chest radiography without and with a 13:1 anti-scatter grid employed.
Anal Sci Adv
December 2025
Chinese Academy of Quality and Inspection & Testing Beijing China.
Single-cell analysis provides critical insights into cellular heterogeneity, dynamic behaviours and microenvironmental interactions, driving advancements in precision medicine and disease mechanism research. However, traditional technologies face limitations due to low throughput, insufficient sensitivity and bottlenecks in multi-omics integration. Microdroplet printing technology, with its advantages in high-throughput single-cell encapsulation, picolitre-level reaction precision and oil-free phase contamination avoidance, has propelled single-cell analysis into a new era of high-throughput and high-dimensional resolution through deep integration with multimodal detection platforms.
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