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http://dx.doi.org/10.1212/NXI.0000000000000821 | DOI Listing |
Pharmacol Res
September 2025
University of Vienna, Department of Pharmaceutical Sciences, Division of Pharmacology and Toxicology, Vienna, Austria. Electronic address:
Hemorrhagic stroke occurs due to a rupture of a blood vessel in the brain. This leads to initial mechanical damage at the site of injury and secondary injuries including axonal degeneration (AxD). Since axons are critical for all brain functions, we systematically reviewed studies that focused on axonal degeneration in two major types of hemorrhagic stroke, intracerebral hemorrhage and subarachnoid hemorrhage, to understand how and to what extent AxD develops and to interrogate underlying mechanisms and potential therapeutic targets.
View Article and Find Full Text PDFInt Immunopharmacol
September 2025
Department of Immunology, Faculty of Biological and Veterinary Sciences, Nicolaus Copernicus University, 1 Lwowska Str., 87-100 Torun, Poland.
Fever-range whole-body hyperthermia (frWBH) is widely used as an adjunctive therapy for various conditions, including rheumatic diseases, psychiatric disorders, and cancer. Despite its extensive application, the biological and immunological mechanisms underlying frWBH remain poorly understood. To investigate the molecular mechanisms driving its therapeutic effects, we conducted a comprehensive analysis encompassing miRNA expression profiling using RT-qPCR, white blood cell (WBC) count assessment, and plasma proteomic profiling immediately following frWBH treatment.
View Article and Find Full Text PDFNeurol Neuroimmunol Neuroinflamm
November 2025
Department of Neurology, UC Davis Medical Center, Sacramento, CA.
Objectives: Complement factor I (CFI) deficiency is a rare condition that can present with fulminant relapsing CNS autoinflammation. In this report, we highlight the utility of genetic testing in unexplained CNS autoinflammation.
Methods: This case report describes a young adult with partial CFI deficiency, presenting with acute hemorrhagic leukoencephalitis and longitudinally extensive transverse myelitis.
JAMA Psychiatry
September 2025
Norman Fixel Institute for Neurological Diseases, University of Florida, Gainesville.
Importance: Behavioral variant frontotemporal dementia (bvFTD), the most common subtype of FTD, is a leading form of early-onset dementia worldwide. Accurate and timely diagnosis of bvFTD is frequently delayed due to symptoms overlapping with common psychiatric disorders, and interest has increased in identifying biomarkers that may aid in differentiating bvFTD from psychiatric disorders.
Objective: To summarize and critically review studies examining whether neurofilament light chain (NfL) in cerebrospinal fluid (CSF) or blood is a viable aid in the differential diagnosis of bvFTD vs psychiatric disorders.
Int J Surg
September 2025
Department of Anesthesiology, Qingdao Municipal Hospital, Qingdao, Shandong Province, China.
Background: As a common postoperative neurological complication, postoperative delirium (POD) can lead to poor postoperative recovery in patients, prolonged hospitalization, and even increased mortality. However, POD's mechanism remains undefined and there are no reliable molecular markers of POD to date. The present work examined the associations of cerebrospinal fluid (CSF) sTREM2 with CSF POD biomarkers, and investigated whether the effects of CSF sTREM2 on POD were modulated by the core pathological indexes of POD (Aβ42, tau, and ptau).
View Article and Find Full Text PDF