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http://dx.doi.org/10.1007/s12253-020-00864-6 | DOI Listing |
J Mol Histol
September 2025
Department of Anatomy and Embryology, Faculty of Medicine, Cairo University, Giza, Egypt.
Cadmium (Cad) is a worldwide heavy metal pollutant associated with global health challenges. Alteration of the intestinal microbiome, due to chemicals' exposure, plays a vital role in the pathogenesis of gastrointestinal diseases such as pancreatic disorders. Hence, modulation of the gut microbiota might be a targeted approach to manage pancreatic diseases.
View Article and Find Full Text PDFMod Pathol
September 2025
Department of Medicine, University of Padua, Italy; Veneto Institute of Oncology, IOV-IRCCS, Padua, Italy. Electronic address:
A subset of gastric cancers (GCs) is linked to Epstein-Barr virus (EBV) infection. This study aims to characterize the histopathological and molecular features of EBV-associated GCs (EBVaGCs), focusing on predictive biomarkers and genomic and transcriptomic analysis. A total of 35 primary EBVaGCs were considered.
View Article and Find Full Text PDFExp Cell Res
September 2025
The First Clinical College, Jinan University, Guangzhou 510632, Guangdong Province, China; Otolaryngology Head and Neck surgery, The First Affiliated Hospital of Bengbu Medical University, Bengbu 233004, Anhui Province, China. Electronic address:
Background: Nasopharyngeal carcinoma (NPC) is a challenging malignancy characterized by aggressive progression and limited therapeutic efficacy. Emerging evidence implicates peroxiredoxin 3 (PRDX3), a mitochondrial peroxidase, as a critical regulator of redox homeostasis and mitochondrial integrity. Given its role in modulating cell death through mitochondrial quality control, we investigated the therapeutic potential of targeting PRDX3 in NPC.
View Article and Find Full Text PDFLab Invest
September 2025
Section of Pediatric Dentistry, Department of Oral Growth and Development, Fukuoka Dental College, Fukuoka, Japan; Oral Medicine Research Center, Fukuoka Dental College, Fukuoka, Japan.
Ameloblastoma (AM) is a benign epithelial odontogenic tumor that occurs in the jawbone. Although benign, AM can exhibit aggressive features, including locally invasive growth. Additionally, local recurrence or distant metastasis may occur.
View Article and Find Full Text PDFAnn Diagn Pathol
August 2025
Department of Pathology, Faculty of Medicine, Ain Shams University, Cairo, Egypt. Electronic address:
Epithelioid mesothelioma (EM) is a pleural malignancy whose many histopathologic patterns may overlap considerably with those of lung adenocarcinoma (LAC) or poorly differentiated squamous cell carcinoma (SCC). This study aimed to evaluate the diagnostic role of SOX6 immunohistochemical expression in EM, study its differential expression in EM, LAC, and SCC, and evaluate the utility of various combinations of SOX6 with established EM markers calretinin and D2-40. The study included 39 EM, 21 LAC, and 11 SCC cases.
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