Evaluation of SOX6 immunohistochemical expression as a diagnostic marker in the distinction of epithelioid mesothelioma from lung carcinomas.

Epithelioid mesothelioma (EM) is a pleural malignancy whose many histopathologic patterns may overlap considerably with those of lung adenocarcinoma (LAC) or poorly differentiated squamous cell carcinoma (SCC). This study aimed to evaluate the diagnostic role of SOX6 immunohistochemical expression in EM, study its differential expression in EM, LAC, and SCC, and evaluate the utility of various combinations of SOX6 with established EM markers calretinin and D2-40. The study included 39 EM, 21 LAC, and 11 SCC cases.

The diagnostic significance of immunohistochemical expression of SOX10 and TRPS1 in triple negative breast cancer.

Triple negative breast cancer (TNBC) usually exhibits heterogeneous morphological features. The absence of a specific targeted marker for the breast origin of TNBC makes the diagnosis of metastatic TNBC challenging. TRPS1 is regarded as a diagnostic marker for breast cancer of various subtypes, including the basal type of TNBC.