Distinct gene network in skin lesion of patients with diffuse cutaneous systemic sclerosis.

Clin Rheumatol

Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.

Published: October 2020


Category Ranking

98%

Total Visits

921

Avg Visit Duration

2 minutes

Citations

20

Article Abstract

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10067-020-05245-7DOI Listing

Publication Analysis

Top Keywords

distinct gene
4
gene network
4
network skin
4
skin lesion
4
lesion patients
4
patients diffuse
4
diffuse cutaneous
4
cutaneous systemic
4
systemic sclerosis
4
distinct
1

Similar Publications

Aim: To investigate the phenotypic and genomic features of three multidrug-resistant (MDR) clinical mucoid and non-mucoid uropathogenic Escherichia coli (UPEC) strains to understand their antimicrobial resistance, biofilm formation, and virulence in urinary tract infections (UTIs).

Methods And Results: The UPEC strains A5, A10, and A15 were isolated from two UTI patients. Phenotypic assays included colony morphology, antibiotic susceptibility, motility, and biofilm formation.

View Article and Find Full Text PDF

The emergence of antimicrobial resistance (AMR) Escherichia coli in poultry farming is a growing global public health concern, particularly in Bangladesh, where the use of antibiotics remains largely unregulated. This study aimed to determine the prevalence and AMR patterns of E. coli isolated from broiler chickens in Sylhet district of Bangladesh and to investigate the network of coexisting resistance traits among the isolates.

View Article and Find Full Text PDF

Genome-wide identification analysis of aldo-keto reductase gene family in cotton and GhAKR40 role in salt stress tolerance.

Funct Integr Genomics

September 2025

Zhengzhou Research Base, State Key Laboratory of Cotton Bio-Breeding and Integrated Utilization, Zhengzhou University/Institute of Cotton Research, Chinese Academy of Agricultural Sciences, Zhengzhou, China.

In this study, a comprehensive genome-wide identification and analysis of the aldo-keto reductase (AKR) gene family was performed to explore the role of Gossypium hirsutumAKR40 under salt stress in cotton. A total of 249 AKR genes were identified with uneven distribution on the chromosomes in four cotton species. The diversity and evolutionary relationship of the cotton AKR gene family was identified using physio-chemical analysis, phylogenetic tree construction, conserved motif analysis, chromosomal localization, prediction of cis-acting elements, and calculation of evolutionary selection pressure under 300 mM NaCl stress.

View Article and Find Full Text PDF

The esterase gene encoding EstJN1 of Clostridium butyricum, which was isolated from the pit cellar of Chinese liquor facility, was expressed. EstJN1 was identified as a novel GDSL esterase belonging to family II. The enzyme demonstrated a marked substrate preference for p-nitrophenyl butyrate, with optimal activity at a temperature of 40 ℃ and a pH of 7.

View Article and Find Full Text PDF

Oxidative stress induces a wide range of cellular damage, often causing disease and cell death. While many organisms are susceptible to the effects of oxidative stress, haloarchaea have adapted to be highly resistant. Several aspects of the haloarchaeal oxidative stress response have been characterized; however, little is known about the impacts of oxidative stress at the translation level.

View Article and Find Full Text PDF