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http://dx.doi.org/10.3967/bes2020.040 | DOI Listing |
Br J Hosp Med (Lond)
August 2025
Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Primary gastric diffuse large B-cell lymphoma (PG-DLBCL) is a common gastrointestinal malignancy. While rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP)-based regimens have improved survival, reliable prognostic tools remain scarce. The International Prognostic Index (IPI), though validated for nodal DLBCL, shows limited accuracy in PG-DLBCL.
View Article and Find Full Text PDFJ Med Case Rep
August 2025
Intensive Care Medicine Department, Aerospace Center Hospital, 15 Yuquan Road, Haidian District, Beijing, China.
Background: Hemophagocytic lymphohistiocytosis is a life-threatening hyperinflammatory syndrome resulting from uncontrolled activation of T cells and macrophages, frequently leading to multiorgan failure. Severe lactic acidosis (lactate ≥ 10 mmol/L), a rare yet critical manifestation, poses unique diagnostic and therapeutic challenges in the intensive care unit. Here, we report two cases of Chinese men with hemophagocytic lymphohistiocytosis presenting with extreme lactic acidosis, highlighting the necessity of early hemophagocytic lymphohistiocytosis screening in intensive care unit patients with unexplained hyperlactatemia.
View Article and Find Full Text PDFFa Yi Xue Za Zhi
April 2025
Department of Forensic Medicine, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450001, China.
Objectives: To analyze the characteristics of methadone-related poisoning cases and provide a reference for forensic identification.
Methods: A total of 71 cases of methadone-related poisoning reported from 1998 to 2023 in China and 26 cases of methadone-related deaths reported from 2013 to 2018 in Italy were retrieved from databases including PubMed, Wanfang and CNKI. The general information, forensic pathological and toxicological characteristics were analyzed.
Fa Yi Xue Za Zhi
April 2025
Department of Forensic Medicine, School of Basic Medical Sciences, Soochow University, Suzhou 215123, Jiang-su Province, China.
Doxorubicin is a commonly used antitumor drug for the treatment of various cancers. However, its clinical application is greatly restricted by its severe cardiotoxicity. At present, doxorubicin-induced cardiotoxicity is categorized into acute and chronic forms, depending on the dosage and duration of exposure, which may eventually lead to the occurrence of heart failure.
View Article and Find Full Text PDFSwiss Med Wkly
July 2025
Department of Gastroenterology, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa (IIS-Princesa), Universidad Autónoma de Madrid (UAM), and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Madrid, Spain.
Background: Helicobacter pylori infection remains prevalent globally. Despite the relatively low reported prevalence in Switzerland, the actual burden is thought to be higher, primarily due to migration. To date, limited evidence is available regarding the effectiveness of Helicobacter pylori eradication therapy in Switzerland.
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