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http://dx.doi.org/10.1016/j.pediatrneurol.2020.03.017 | DOI Listing |
Introduction: Surgical resection of intracranial tumors in pediatric patients poses the potential risk of new-onset postoperative seizures, prompting debates over the prophylactic use of anti-seizure medication(ASMs). This retrospective study focusses on the incidence and risk factors associated with the occurrence of new-onset postoperative seizures within 30 days following surgery in pediatric patients with brain tumors who did not receive ASM prophylaxis pre- and perioperatively.
Methods: A meticulous review of clinical records spanning from June 2018 to December 2022 was conducted, examining data from pediatric patients undergoing craniotomies for intracranial tumors.
Clin Neurol Neurosurg
October 2025
Department of Neurosurgery, Boston Medical Center, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA. Electronic address:
Introduction/objectives: Seizures are common postoperative complications for patients who have undergone surgical management for traumatic brain injury (TBI). However, little is known regarding preoperative factors that predict them. This study aims to describe preoperative factors that influence the occurrence of seizures after surgery for TBI.
View Article and Find Full Text PDFInt J Clin Pharm
August 2025
Department of Pharmacy, Medical Supplies Center, Chinese PLA General Hospital, No.28 Fuxing Road, Haidian District, Beijing, 100853, China.
Introduction: Drug-induced movement disorders (DIMDs) are often underrecognized and challenging to diagnose and manage in clinical practice. Sodium valproate (VPA), a widely prescribed antiepileptic drug, causes DIMDs. Predictive modeling based on electronic medical records and machine learning algorithms offers a promising approach to improve early identification of adverse drug reactions (ADRs) and enhance clinical safety.
View Article and Find Full Text PDFJ Headache Pain
August 2025
Department of Neurology, Lanzhou University Second Hospital, Cuiying Gate, No. 82 Linxia Road, Chengguan District, Lanzhou, 730000, China.
Background: Migraine episodes are known to induce heightened photosensitivity. Neuroimaging investigations have revealed that the primary visual cortex exhibits abnormal activation patterns both during and between migraine attacks. Growing evidence suggests that altered cortical activity patterns may underlie the pathophysiology of neurological disorders.
View Article and Find Full Text PDFBMC Neurol
August 2025
Department of research, Medical Research circle, Goma, Democratic Republic of the Congo.
Background: Migraine is a complex neurological disorder characterized by recurrent, disabling headaches and various sensory symptoms, affecting about 15% of the global population annually. It is the second most common neurological condition worldwide, causing significant disability. While current prophylactic treatments include beta-blockers, tricyclic antidepressants, anticonvulsants, and monoclonal antibodies targeting the CGRP pathway, not all patients respond adequately.
View Article and Find Full Text PDF