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The common marmoset (Callithrix jacchus), a New World monkey, is emerging as a promising animal model for biomedical and neuroscience research. This species shares its basic brain architecture, including the organization of the motor cortical areas and the connections between these and other areas, with humans and other primates. Its small and lissencephalic cerebral cortex is suitable for the application of modern biological techniques. Optogenetic stimulation of the motor cortex induces forelimb movements, and two-photon calcium imaging allows detection of forelimb movement-related activity in multiple motor cortical neurons. The common marmoset also has a large repertoire of forelimb-related behaviors and vocal communications. Thus, the common marmoset is a good model for research into voluntary forelimb movements, social behaviors, and their dysfunctions.
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http://dx.doi.org/10.1016/j.conb.2020.02.013 | DOI Listing |
Cell Rep
August 2025
Laboratory of Animal Resources, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. Electronic address:
Fragile X syndrome (FXS) is the foremost monogenic cause of autism spectrum disorder and intellectual disability, caused by FMR1 gene silencing. Here, we report that common marmosets carrying FMR1 mutation, a non-human primate model for FXS, share common features in behavioral and molecular phenotypes with patients with FXS. Founder mutants with markedly reduced fragile X messenger ribonucleoprotein expression display hyperactivity, spontaneous seizures, and transcriptome changes in synapse-related genes that overlap with those reported in patients with FXS.
View Article and Find Full Text PDFActa Trop
September 2025
College of Veterinary Medicine, Anhui Agricultural University, Hefei, Anhui Province 230036, China. Electronic address:
Trichomonads are flagellated protozoan parasites, some of which are pathogenic and have zoonotic potential. This study aimed to investigate the prevalence, genetic diversity, phylogenetic relationships and risk of trichomonads in captive non-human primates (NHPs) in China. Data on trichomonad prevalence and diversity in captive NHPs are limited.
View Article and Find Full Text PDFJ Neurosci
September 2025
Centre for Functional and Metabolic Mapping, Robarts Research Institute, University of Western Ontario, London, Ontario, Canada.
Vocal communication is a complex social behavior that entails the integration of auditory perception and vocal production. Both anatomical and functional evidence have implicated the anterior cingulate cortex (ACC), including area 32, in these processes, but the dynamics of neural responses in area 32 during naturalistic vocal interactions remain poorly understood. Here, we addressed this by recording the activity of single area 32 neurons using chronically implanted ultra high density Neuropixels probes in freely moving male common marmosets () engaged in an antiphonal calling paradigm in which they exchanged long-distance "phee" calls with a virtual conspecific.
View Article and Find Full Text PDFbioRxiv
August 2025
Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21025, USA.
In auditory cortex, neural responses to stimuli inside receptive fields (RFs) can be further facilitated by behavioral demands, such as attending to a spatial location. It is less clear how off-RF stimuli modulate neural responses and contribute to behavioral tasks. Our recent study revealed a particular form of location-specific facilitation evoked by repeated stimulation from an off-RF location, suggesting behavioral modulation of spatial RFs.
View Article and Find Full Text PDFFront Aging Neurosci
August 2025
Research Center for Global Agromedicine, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Japan.
The aim of this study was to explore and discuss efficient and effective mammalian models for Alzheimer's disease (AD). In this study, efficient AD models are characterized by a small body size, a short lifespan, and rapid development of the main pathology including amyloid plaque formation. Effective AD models are expected to exhibit not only the main pathology, but also co-pathology associated with other neurodegenerative diseases (e.
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