Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Fluorescence guided neurosurgery based on 5-aminolevulinic acid (5-ALA) has significantly increased maximal safe resections. Fluorescence lifetime imaging (FLIM) of 5-ALA could further boost this development by its increased sensitivity. However, neurosurgeons require real-time visual feedback which was so far limited in dual-tap CMOS camera based FLIM. By optimizing the number of phase frames required for reconstruction, we here demonstrate real-time 5-ALA FLIM of human high- and low-grade glioma with up to 12 Hz imaging rate over a wide field of view (11.0 x 11.0 mm). Compared to conventional fluorescence imaging, real-time FLIM offers enhanced contrast of weakly fluorescent tissue.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7075617 | PMC |
| http://dx.doi.org/10.1364/BOE.382817 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Preclinical Investigations Toward Gd-free Molecularly Targeted Dual-Modal, MRI Dynamic (DCE-MRI)/Optical Imaging Contrast Agent for Cardiac Angiosarcoma.
Top Magn Reson Imaging
October 2025
BIOSPACE LAB, Nesles-la-Vallée, France.
Aims: Cardiac tumors are aggressive and asymptomatic in early stages, causing late diagnosis and locoregional metastasis. Currently, the standard of care uses gadolinium-based contrast agents for MRI, and the associated hypersensitivity reactions are a significant concern, such as gadolinium deposition disease. In addition, the proximity of cardiac lesions closer to vital structures complicates surgical interventions.
View Article and Find Full Text PDFIonic Liquid Engineered Defect-Driven Green Emitting Zero-Dimensional CsPbBr Microdisks.
J Phys Chem Lett
September 2025
School of Chemical Sciences, National Institute of Science Education and Research (NISER), An OCC of Homi Bhabha National Institute Jatni, Khurda, Bhubaneswar 752050, Odisha, India.
Quantum-confined perovskites represent an emerging class of materials with great potential for optoelectronic applications. Specifically, zero-dimensional (0D) perovskites have garnered significant attention for their unique excitonic properties. However, achieving phase-pure, size-tunable 0D perovskite materials and gaining a clear understanding of their photophysical behavior remains challenging.
View Article and Find Full Text PDFEnhancing Blue Emission in Poly(‑vinylcarbazole): Synthesis, Functionalization with Anthracene, and Mitigation of Aggregation-Caused Quenching.
ACS Omega
September 2025
Instituto de Macromoléculas Professora Eloisa Mano, Universidade Federal do Rio de Janeiro (IMA/UFRJ), Rio de Janeiro, Rio de Janeiro 21941-598, Brazil.
This study reports the synthesis and functionalization of poly-(-vinylcarbazole) (PVK) with anthracene units to enhance its blue photoluminescence properties. Structural and thermal analyses confirmed successful incorporation of anthracene moieties into the PVK backbone at an approximate 3:1 ratio of PVK repeat unit to anthracene. Photophysical characterization showed that anthracene-functionalized PVK (PVK-An) retained blue-region emission (432 nm), although with reduced emission efficiency due to π-π stacking interactions.
View Article and Find Full Text PDFInfluence of Starch-Granule Diameter on Lasing Thresholds of the Molecular Rotor Thioflavin T in a Dual-Cavity Fabry-Perot/Whispering Gallery Mode.
ACS Omega
September 2025
Center of Cellular Immunotherapies, Warsaw University of Life Sciences, Warsaw 02-786, Poland.
A dual-cavity lasing platform is reported in which thioflavin T (ThT), a rotor-sensitive molecular probe, is employed to map molecular-crowding effects within starch granules via coupled Fabry-Perot (FP) and whispering gallery mode (WGM) resonances. In this architecture, global standing-wave feedback is furnished by a planar FP cavity, while size-tunable WGMs are supported by ThT-coated starch granules. Granules were sorted into five diameter classes (<20, 20-30, 30-40, 40-60, and >60 μm), and lasing thresholds alongside fluorescence lifetimes were determined.
View Article and Find Full Text PDFEpitaxial Growth of Blue-Emitting CsPbBr Nanocrystals on a Pb-Doped LDH Matrix and Application in White LEDs.
ACS Appl Mater Interfaces
September 2025
School of Chemistry & Materials Engineering, Fuyang Normal University, Fuyang 236037, China.
Halide perovskite quantum dots (QDs) have demonstrated outstanding performance in light-emitting applications. However, the performance of blue perovskite QDs lags far behind that of their red and green counterparts, especially those with color coordinates approaching (0.131, 0.
View Article and Find Full Text PDF