Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Rationale: Pulmonary function testing (PFT) provides diagnostic information regarding respiratory physiology. However, many forms of PFT are time-intensive and require patient cooperation. Respiratory inductance plethysmography (RIP) provides thoracoabdominal asynchrony (TAA) and work of breathing (WOB) data. pneuRIPTM is a noninvasive, wireless analyzer that provides real-time assessment of RIP via an iPad. In this study, we show that pneuRIPTM can be used in a hospital clinic setting to differentiate WOB indices and breathing patterns in children with DMD as compared to age-matched healthy subjects.
Methods: RIP using the pneuRIPTM was conducted on 9 healthy volunteers and 7 DMD participants (ages 5-18) recruited from the neuromuscular clinic, under normal resting conditions over 3-5 min during routine outpatient visits. The tests were completed in less than 10 minutes and did not add excessive time to the clinic visit. Variables recorded included labored-breathing index (LBI), phase angle (Φ) between abdomen and rib cage, respiratory rate (RR), percentage of rib cage input (RC%), and heart rate (HR). The data were displayed in histogram plots to identify distribution patterns within the normal ranges. The percentages of data within the ranges (0≤ Φ ≤30 deg.; median RC %±10%; median RR±5%; 1≤LBI≤1.1) were compared. Unpaired t-tests determined significance of the data between groups.
Results: 100% patient compliance demonstrates the feasibility of such testing in clinical settings. DMD patients showed a significant elevation in Φ, LBI, and HR averages (P<0.006, P<0.002, P<0.046, respectively). Healthy subjects and DMD patients had similar BPM and RC% averages. All DMD data distributions were statistically different from healthy subjects based on analysis of histograms. The DMD patients showed significantly less data within the normal ranges, with only 49.7% Φ, 48.0% RC%, 69.2% RR, and 50.7% LBI.
Conclusion: In this study, noninvasive pneuRIPTM testing provided instantaneous PFT diagnostic results. As compared to healthy subjects, patients with DMD showed abnormal results with increased markers of TAA, WOB indices, and different breathing patterns. These results are similar to previous studies evaluating RIP in preterm infants. Further studies are needed to compare these results to other pulmonary testing methods. The pneuRIPTM testing approach provides immediate diagnostic information in outpatient settings.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6953871 | PMC |
| http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0226980 | PLOS |
Publication Analysis
Top Keywords
Similar Publications
Can't Hold any More! A Large Survey on Cycling Subjective Experience at the Limit of Effort.
Psychol Sport Exerc
September 2025
Department of Experimental Psychology, University of Granada, Granada, Spain; Mind, Brain and Behavior Research Center (CIMCYC), University of Granada, Granada, Spain.
Cyclists frequently experience task failure, an abrupt inability to maintain high-intensity effort, pushing both physiological and psychological boundaries. Although the physiological underpinnings of task failure are well-documented, the associated subjective and perceptual experiences remain underexplored. To address this gap, we surveyed 2,818 licensed cyclists, gathering extensive data on the subjective aspects of reaching the point of exhaustion.
View Article and Find Full Text PDFThe airway-brain axis: Connecting breath, brain, and behavior.
Cell Rep
September 2025
Department of Biology, MIT, Cambridge, MA 02139, USA; Department of Brain and Cognitive Sciences, MIT, Cambridge, MA 02139, USA; Picower Institute for Learning and Memory, MIT, Cambridge, MA 02139, USA; Biology of Adversity Project, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Elect
The neural control of breathing is both dynamic and essential, ensuring life-sustaining gas exchange while protecting the respiratory system from harm. Peripheral neurons innervating the respiratory tract exhibit remarkable diversity, continuously relaying sensory feedback to the brain to regulate breathing, trigger protective reflexes such as coughing and sickness behaviors, and even influence emotional states. Understanding this airway-brain axis is especially critical given the increasing global burden of respiratory diseases, as it holds implications for both human health and broader brain-body interactions.
View Article and Find Full Text PDFThe Role of the Midbrain Tegmentum in the Regulation of Breathing Patterns in Carp (Cyprinus carpio) and Trout (Onchorhynchus mykiss).
Respir Physiol Neurobiol
September 2025
Department of Zoology, University of British Columbia, Vancouver, British Columbia, Canada, V6T1Z4. Electronic address:
In vertebrates, the basic respiratory rhythm is modified by both sensory feedback and input from higher centers to produce a broad range of breathing patterns. In carp (Cyprinus carpio L.), breathing is often episodic while in trout (Onchorhynchus mykiss) it is continuous and rhythmic except when water is hyperoxic.
View Article and Find Full Text PDFSporadic lymphangioleiomyomatosis in young female patient: A case report and review of the literature.
Int J Surg Case Rep
September 2025
Department of Internal Medicine, Pulmonology and Critical Care Unit, Bahir Dar University, Bahir Dar, Ethiopia.
Introduction And Importance: Lymphangioleiomyomatosis (LAM) is a rare disorder of unknown cause which mostly affects young females and involving multi organ system with primarily involving lung.
Presentation Of Case: A 35 year's old female Ethiopian known hypertension patient from Debre Tabor, Ethiopia, Africa; presented with progressively increasing cough with blood tingled sputum of 1-2 Arabic coffee cup per day, progressively increasing exertional shortness of breath and easy fatigability seven years back. Hypertensive and desaturate to level of 88 % at atmospheric air.
Interpreting the mandibular jaw movement signal in pediatric obstructive sleep apnea diagnosis: A technical and practical review.
Sleep Med Rev
August 2025
Department of Pediatrics, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV, USA.
Pediatric obstructive sleep apnea (OSA) is a common yet often underdiagnosed condition, partly due to limited access to polysomnography. Mandibular jaw movement (MJM) analysis offers a promising alternative to conventional home sleep apnea testing in children, capturing the dynamic interactions between respiratory drive and upper airway musculature, enabling accurate identification of, and critical insights into, sleep-disordered breathing events. This technical and practical review provides a structured framework for understanding and interpreting MJM signals during sleep in pediatric patients.
View Article and Find Full Text PDF