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Primary orbital chondromyxoid fibroma is a rarely reported entity. A 34-year-old lady presented with painless, non-axial proptosis of the left eye of 6 months duration. Orbital imaging showed a supero-temporal mass with calcific foci and bone erosion. The mass caused globe compression resulting in choroidal folds. Anterior orbitotomy with complete mass excision was performed. The histopathology revealed a chondromyxoid fibroma. At 12-months follow-up, the patient is doing fine with no clinical recurrence. Chondromyxoid fibroma is an important differential diagnosis for bony orbital tumors.
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http://dx.doi.org/10.4103/ijo.IJO_1275_19 | DOI Listing |
J Orthop Case Rep
August 2025
Department of Orthopaedics Osmania Medical College, Hyderabad, Telangana, India.
Introduction: The clavicle is an uncommon site for tumors, as it is a flat bone and rarely affected by neoplasms. Most clavicular tumors are malignant, with metastases and Ewing's sarcoma being the most common. Overall, clavicular neoplasms account for <1% of all bone tumors, and chondromyxoid fibroma (CMF) is particularly rare, comprising <1% of cases.
View Article and Find Full Text PDFSurg Pathol Clin
September 2025
Department of Pathology, Leiden University Medical Center, Albinusdreef 2, Leiden 2333 ZA, The Netherlands. Electronic address:
Cartilage tumors consist of a heterogeneous group of neoplasms characterized by the production of cartilage. Benign cartilage tumors generally exhibit slow growth and indolent behavior, while chondrosarcoma are more aggressive. Due to the overlapping morphology of cartilage tumors, integration of clinical, radiological, histologic and molecular data is needed to establish the correct diagnosis.
View Article and Find Full Text PDFSultan Qaboos Univ Med J
July 2025
Department of Surgery, Sultan Qaboos University Hospital, University Medical City, Muscat, Oman.
Chondromyxoid fibromas (CMFs) are rare tumours that comprise less than 2% of benign bone tumours; approximately 5-7.9% occur in the ribs. We report a 28-year-old female patient with CMF in the 4th rib that presented to a tertiary care hospital in Muscat, Oman, in 2023.
View Article and Find Full Text PDFSultan Qaboos Univ Med J
July 2025
Departments of Pathology, Command Hospital, Kolkata, India.
Chondromyxoid fibroma (CMF) is a rare, benign metaphyseal bone tumour characterised by a combination of chondroid, myxoid, and fibrous elements. It can affect any bone at any age, with no gender predilection. We report a case of CMF in a 47-year-old female patient who presented with swelling of the left little finger at a tertiary care hospital in Kolkata, India, in 2024.
View Article and Find Full Text PDFZhonghua Bing Li Xue Za Zhi
June 2025
Department of Pathology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200233, China.
Cartilage tumors are a group of mesenchymal neoplasms characterized by tumor cells that produce cartilage matrix.The molecular pathology of cartilage tumors, as outlined in the 5th edition WHO classification, has been significantly updated.Key updates include: isocitrate dehydrogenase 1/2 mutations in enchondoma and chondrosarcoma, H3F3B mutations in chondroblastoma, NCOA2 rearrangements in mesenchymal chondrosarcoma, and GRM1 gene fusion and promoter replacement are associated with chondromyxoid fibroma, etc.
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