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http://dx.doi.org/10.1038/d41586-019-03114-1 | DOI Listing |
J Exp Med
November 2025
Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA.
Host-pathogen interactions involve two critical strategies: resistance, whereby hosts clear invading microbes, and tolerance, whereby hosts carry high pathogen burden asymptomatically. Here, we investigate mechanisms by which Salmonella-superspreader (SSP) hosts maintain an asymptomatic state during chronic infection. We found that regulatory T cells (Tregs) are essential for this disease-tolerant state, limiting intestinal immunopathology and enabling SSP hosts to thrive, while facilitating Salmonella transmission.
View Article and Find Full Text PDFGut Microbes
December 2025
Clinical Microbiome Unit, Laboratory of Host Immunity and Microbiome, Division of Intramural Research, National Institute of Allergy and Infectious Disease, National Institute of Health, Bethesda, MD, USA.
Parity, the number of pregnancies carried beyond 20 weeks, influences the maternal gut microbiome. However, whether parity modulates the infant microbiome longitudinally remains underexplored. To address this, 746 infants in a longitudinal cohort study were assessed.
View Article and Find Full Text PDFGut Microbes
December 2025
Cancer Research Laboratory, Chengde Medical College, Chengde, Hebei, China.
Genetic predisposition and environmental factors, including psychological stress, play prominent roles in driving the development and progression of colorectal neoplasms. However, the mechanisms through which chronic stress drives the progression of colorectal neoplasm remain unclear. The gut microbiota is closely linked to chronic psychological stress (chronic stress) and colorectal neoplasms.
View Article and Find Full Text PDFJ Integr Neurosci
August 2025
Department of Medicine, University of Alberta, Edmonton, AB T6G 2R3, Canada.
There is a growing body of evidence that the interaction between various microbial organisms and the human host can affect various physical and even mental health conditions. Bidirectional communication occurs between the brain and the gut microbiome, referred to as the brain-gut-microbiome axis. During aging, changes occur to the gut microbiome due to various events and factors such as the mode of delivery at birth, exposure to medications (e.
View Article and Find Full Text PDFFront Microbiol
August 2025
Institute of Animal Science, Ningxia Academy of Agriculture and Forestry, Yinchuan, Ningxia, China.
Introduction: Inflammation and oxidative stress can seriously endanger the health and growth of beef cattle. Georgi (SB) has significant anti-inflammatory and antioxidative effects. However, studies on the application of SB stems and leaves as roughage in animal husbandry are limited.
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