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Article Abstract
Macrocyclic hosts have long been the workhorses of molecular recognition. Despite the widespread use of container-shaped molecules as synthetic receptors, an efficient preparation of cavitands bearing multiple functional groups has not been realized. This Letter describes a new cavitand derived from a sequence-defined oligoamide foldamer scaffold. A solid-phase synthesis approach is reported, which enables the display of multiple chemically diverse functional groups on the cavitand rim.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6781098 | PMC |
| http://dx.doi.org/10.1021/acs.orglett.9b02708 | DOI Listing |
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