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Ultracold molecules have important applications that range from quantum simulation and computation to precision measurements probing physics beyond the Standard Model. Optical tweezer arrays of laser-cooled molecules, which allow control of individual particles, offer a platform for realizing this full potential. In this work, we report on creating an optical tweezer array of laser-cooled calcium monofluoride molecules. This platform has also allowed us to observe ground-state collisions of laser-cooled molecules both in the presence and absence of near-resonant light.
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http://dx.doi.org/10.1126/science.aax1265 | DOI Listing |
J Thromb Haemost
September 2025
Department of Immunology and Inflammation, Centre for Haematology, Imperial College, London, UK. Electronic address:
Background: The VWF Phe2561Tyr variant has been previously shown to exhibit gain-of-function like activity and increase the risk of repeated MI in patients below 55 years of age. It was hypothesised that altered stem dynamics enhanced the responsiveness of the molecule to shear stress. In this study we investigated the evolutionary significance of the amino acid at position 2561 and functional impacts of variants at this site.
View Article and Find Full Text PDFUnlabelled: Homologous recombination (HR) is a DNA double-strand break repair pathway that facilitates genetic exchange and protects damaged replication forks during DNA synthesis. As a template-based repair process, the successful repair of a double-strand break depends on locating suitable homology from a donor DNA sequence elsewhere in the genome. In eukaryotes, Rad51 catalyzes the homology search in coordination with the ATP-dependent motor protein Rad54.
View Article and Find Full Text PDFPoly[ADP-ribose] polymerase 1 (PARP1) detects DNA strand breaks that occur in duplex DNA and chromatin. We employed correlative optical tweezers and fluorescence microscopy to quantify how single molecules of PARP1 identify single-strand breaks (i.e.
View Article and Find Full Text PDFJ Phys Chem Lett
September 2025
Department of Chemistry and Biochemistry, Kent State University, Kent, Ohio 44242, United States.
Liquid-liquid phase separation (LLPS) is a newly discovered phenomenon to modulate a multitude of cellular functions. Despite its importance, the full evolution mechanism of LLPS starting from intramolecular interactions to intermolecular condensations has yet to be revealed. In this study, we investigated a representative LLPS formed between negatively charged nucleic acids poly(G-quadruplex) and positively charged peptides poly(lysine).
View Article and Find Full Text PDFJ Biophotonics
September 2025
Institute for Physical Research of National Academy of Sciences of Armenia, Ashtarak, Armenia.
We report the results of an experimental study of the movement and trapping of Gram-negative Escherichia coli (E. coli) bacteria in broth suspensions, under photovoltaic fields generated by an optical Bessel beam illumination of the surface of a lithium niobate crystal (photovoltaic tweezers). The study was performed using a phase-sensitive transmission microscope.
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