Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Controlled trunk motion is crucial for balance and stability during walking. Persons with lower extremity amputation often exhibit abnormal trunk motion, yet underlying mechanisms are not well understood nor have optimal clinical interventions been established. The aim of this work was to characterize associations between altered lower extremity joint moments and altered trunk dynamics in persons with unilateral, transtibial amputation (TTA). Full-body gait data were collected from 10 persons with TTA and 10 uninjured persons walking overground (~1.4 m/s). Experimentally-measured trunk angular accelerations were decomposed into constituent accelerations caused by net joint moments throughout the body using an induced acceleration analysis. Results showed persons with TTA had similar ankle moment magnitude relative to uninjured persons (P > 0.05), but greater trunk angular acceleration induced by the prosthetic ankle which acted to lean the trunk ipsilaterally (P = 0.003). Additionally, persons with TTA had a reduced knee extensor moment relative to uninjured persons (P < 0.001), resulting in lesser sagittal and frontal induced trunk angular accelerations (P < 0.001). These data indicate kinetic compensations at joints other than the lumbar and hip contribute to altered trunk dynamics in persons with a unilateral TTA. Findings may inform development of new clinical strategies to modify problematic trunk motion.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6706581 | PMC |
| http://dx.doi.org/10.1038/s41598-019-47796-z | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Multicellular tumor-stromal interactions recapitulate aspects of therapeutic response and human oncogenic signaling in a 3D disease model for H3K27M-altered DIPG.
Oncogene
September 2025
Division of Neurosurgery, Children's Hospital Los Angeles, Los Angeles, CA, USA.
It has become evident from decades of clinical trials that multimodal therapeutic approaches with focus on cell intrinsic and microenvironmental cues are needed to improve understanding and treat the rare, inoperable, and ultimately fatal diffuse intrinsic pontine glioma (DIPG), now categorized as a diffuse midline glioma. In this study we report the development and characterization of an in vitro system utilizing 3D Tumor Tissue Analogs (TTA), designed to replicate the intricate DIPG microenvironment. The innate ability of fluorescently labeled human brain endothelial cells, microglia, and patient-derived DIPG cell lines to self-assemble has been exploited to generate multicellular 3D TTAs that mimic tissue-like microstructures, enabling an in- depth exploration of the spatio-temporal dynamics between neoplastic and stromal cells.
View Article and Find Full Text PDFFactors influencing stifle stability in canine limb press models: A systematic review and meta-analysis.
Res Vet Sci
October 2025
Department of Veterinary Clinical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Dyrlægevej 16, 1870 Frederiksberg C, Denmark. Electronic address:
Limb press models have been widely used to explore aspects of canine stifle stability and to inform surgical practice. This systematic review aimed to synthesize test conditions, periarticular forces, and stability measures in canine limb press models for comparison with in vivo measurements. Six databases (EMBASE, Ovid MEDLINE, CAB abstracts, Agricola, Scopus, and Web of Science) were searched from inception to 17.
View Article and Find Full Text PDFBackground: Unicompartmental knee arthroplasty (UKA), high tibial osteotomy (HTO), and distal femoral osteotomy (DFO) are common knee-preserving surgeries for knee osteoarthritis (KOA), yet systematic comparisons of their effects on lower limb biomechanical parameters remain limited.
Objective: To retrospectively evaluate and compare the impacts of UKA, HTO, and DFO on hip-knee-ankle alignment in KOA patients, providing evidence for personalized surgical strategy formulation. We hypothesized that these procedures would exert differential effects on specific alignment parameters.
Lanthanide organic-inorganic hybrid fluorescent materials are considered as promising candidates for next-generation lighting materials due to their unique optical properties and potential applications. In this work, commercialized silica materials (fumed silica) were selected as the carrier. By means of the bridging function of silane coupling agents, Eu(TTA)(Phen) was covalently grafted onto the surface of fumed silica to synthesize lanthanide hybrid phosphors.
View Article and Find Full Text PDFImpact of gadolinium oxide based nanoparticles on genotoxic, cytotoxic and oxidative stress in human lymphocytes.
Toxicol In Vitro
December 2025
Laboratorio de Genética, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Av. Wilfrido Massieu s/n, Zacatenco, Ciudad de México 07738, México. Electronic address:
Gadolinium-based nanoparticles are presently applied in biomedicine and industry, and their potential is increasing. In this report we synthetized three nanoparticles by the sol-gel, supercritical drying method: GdO, GdO doped with Eu, and GdO doped with Euand functionalized with thenoyltrifluoroacetone (TTA). The nanoparticles were characterized for luminescence, morphology, size, and Z potential.
View Article and Find Full Text PDF