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Lane detection is an important foundation in the development of intelligent vehicles. To address problems such as low detection accuracy of traditional methods and poor real-time performance of deep learning-based methodologies, a lane detection algorithm for intelligent vehicles in complex road conditions and dynamic environments was proposed. Firstly, converting the distorted image and using the superposition threshold algorithm for edge detection, an aerial view of the lane was obtained via region of interest extraction and inverse perspective transformation. Secondly, the random sample consensus algorithm was adopted to fit the curves of lane lines based on the third-order B-spline curve model, and fitting evaluation and curvature radius calculation were then carried out on the curve. Lastly, by using the road driving video under complex road conditions and the Tusimple dataset, simulation test experiments for lane detection algorithm were performed. The experimental results show that the average detection accuracy based on road driving video reached 98.49%, and the average processing time reached 21.5 ms. The average detection accuracy based on the Tusimple dataset reached 98.42%, and the average processing time reached 22.2 ms. Compared with traditional methods and deep learning-based methodologies, this lane detection algorithm had excellent accuracy and real-time performance, a high detection efficiency and a strong anti-interference ability. The accurate recognition rate and average processing time were significantly improved. The proposed algorithm is crucial in promoting the technological level of intelligent vehicle driving assistance and conducive to the further improvement of the driving safety of intelligent vehicles.
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http://dx.doi.org/10.3390/s19143166 | DOI Listing |
ACS Omega
September 2025
Global Drug Metabolism and Pharmacokinetics, Eisai Co., Ltd.Tokodai 5-1-3, Tsukuba, Ibaraki 300-2635, Japan.
Irsenontrine is a novel phosphodiesterase-9 inhibitor that has been developed for the treatment of cognitive dysfunction. To assess the pharmacokinetics, excretion, and distribution of the drug in humans, comprehensive assays for irsenontrine were developed using liquid chromatography with tandem mass spectrometry (LC-MS/MS) in three human matrices, including plasma, urine, and cerebrospinal fluid (CSF). Irsenontrine was extracted from the matrices by a straightforward protein precipitation method and subsequently separated on a reverse-phase column.
View Article and Find Full Text PDFMol Ther Methods Clin Dev
September 2025
School of Natural Sciences, University of Kent, Canterbury, Kent CT2 7NJ, UK.
Accurate quantification and characterization of recombinant adeno-associated virus (rAAV) capsid proteins are critical for evaluating product quality and safety, ensuring batch consistency, and informing process development of their manufacture. The capsid consists of three proteins derived from the same gene, and while the mean capsid stoichiometry is nominally 1:1:10 (VP1:VP2:VP3), capsids with different stoichiometries exist. Recent studies show that variations in the capsid stoichiometry can impact vector infectivity.
View Article and Find Full Text PDFBiomed Phys Eng Express
September 2025
Institute of Electrical Engineering Chinese Academy of Sciences, No.6, Zhongguancun Road, Haidian District, Beijing , China, Beijing, Beijing, 100190, CHINA.
Objective: Transcranial magnetic stimulation (TMS) is a promising neuromodulation therapy for treating diseases such as depression and Alzheimer's disease. However, its efficacy depends on precise magnetic field targeting. Current measurement methods face a trade-off between accuracy and complexity.
View Article and Find Full Text PDFBiology (Basel)
August 2025
Turtle Survival Alliance, 5900 Core Road, Suite 504, North Charleston, SC 29406, USA.
The Florida softshell turtle, , is considered common and found in many different types of freshwater habitats throughout its range. However, despite its prevalence where it occurs, little is understood about the species' life history and population dynamics due to difficulties with capture and long-term marking. Building on a foundational study of the Florida softshell turtle at Wekiwa Springs State Park (WSSP) from 2007 to 2012, we present findings from an extended 16-year mark-recapture study spanning from 2007 to 2023.
View Article and Find Full Text PDFACS Nano
September 2025
College of Physics, Donghua University, Shanghai 201620, China.
Broadband anisotropic photodetectors show great promise for polarization-sensitive imaging and multispectral optoelectronic systems yet face critical challenges in material anisotropy modulation and broadband sensitivity. Weyl semimetals exhibit giant optical anisotropy and tunable heterojunction band alignment, enabling high-performance anisotropic photodetection. Herein, ultrabroadband PDs based on the NbNiTe (niobium nickel telluride), enabled by antenna integration and heterostructure engineering, achieve high sensitivity from visible to Terahertz (THz).
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