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CNS Drugs
September 2025
Global Health Neurology Lab, Sydney, NSW, 2150, Australia.
Acute ischemic stroke (AIS) remains a leading cause of mortality and long-term disability globally, with survivors at high risk of recurrent stroke, cardiovascular events, and post-stroke dementia. Statins, while widely used for their lipid-lowering effects, also possess pleiotropic properties, including anti-inflammatory, endothelial-stabilizing, and neuroprotective actions, which may offer added benefit in AIS management. This article synthesizes emerging evidence on statins' dual mechanisms of action and evaluates their role in reducing recurrence, improving survival, and mitigating cognitive decline.
View Article and Find Full Text PDFBackground: This study investigated the clinical significance of rods and rings (RR) immunofluorescence patterns in antinuclear antibody (ANA) testing by analyzing their clinical associations.
Methods: A single-center retrospective analysis was conducted between January 2022 and December 2023, examining cases with RR patterns in ANA testing.
Results: Among 40 cases (0.
Adv Mater
September 2025
State Key Laboratory of Crystal Materials, Shandong University, Jinan, Shandong, 250100, P. R. China.
Electrical deep brain stimulation is effective for epilepsy suppression, but will lead to neural tissue damage and inflammation due to implantation of electrodes and a pulse generator. Transcranial magnetic and transcranial ultrasound stimulation cannot directly generate effective electrical signals in deep brain regions. Here, the use of piezoelectric nanoparticles is proposed as wireless nanostimulators for deep brain electrical stimulation and minimally invasive suppression of epilepsy.
View Article and Find Full Text PDFPhotodiagnosis Photodyn Ther
September 2025
Institute of Medical Engineering and Mechatronics, Ulm University of Applied Sciences, Albert-Einstein-Allee 55, 89081 Ulm, Germany.
Bacterial inflammatory skin conditions, especially those caused by Cutibacterium acnes (C. acnes), are among the most common skin diseases globally. While C.
View Article and Find Full Text PDFChem Sci
August 2025
Shanghai Key Laboratory of Functional Materials Chemistry, Institute of Fine Chemicals, Frontiers Science Center for Materiobiology and Dynamic Chemistry, School of Chemistry and Molecular Engineering, East China University of Science and Technology Shanghai 200237 China
Real-time monitoring of senescent cells is of great significance for understanding and intervening in aging. Since overexpression of endogenous β-galactosidase (β-gal) is not unique to senescent cells, probes relying solely on β-gal activity could yield inaccurate senescent cell detection. Herein, we designed a dual-mode sequential response AND logic NIR probe MFB-βgal, which contains a β-gal-cleavable unit and a morpholine unit, serving as an enzymatic activity trigger and a lysosomal targeting moiety, respectively.
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