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This paper studies the prototype development for the self-propelled capsule system which is driven by autogenous vibrations and impacts under external resistance forces. This project aims for proof-of-concept of its locomotion in pipeline environment in order to mitigate the technical complexities and difficulties brought by current pressure-driven pipeline inspection technologies. Non-smooth multibody dynamics is applied to describe the motion of the capsule system, and two non-smooth nonlinearities, friction and impact, are considered in modelling. The prototype of the self-propelled capsule system driven by a push-type solenoid with a periodically excited rod has been designed to verify the modelling approach. The prototype contains a microcontroller, a power supply, and a wireless control module, which has been tested in a clear uPVC pipe via remote control. Various control parameters, e.g. impact stiffness, frequency and amplitude of excitation, are studied experimentally, and finally, the fastest progression of the system is obtained.
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http://dx.doi.org/10.1007/s11012-017-0801-3 | DOI Listing |
Med Phys
September 2025
Medical Physics Unit, Department of Oncology, Faculty of Medicine, McGill University, Montréal, Québec, Canada.
Background: Se ( 120 days, 215 keV) offers advantages over Ir ( 74 days, 360 keV) as a high dose rate brachytherapy source due to its lower gamma energy and longer half-life. Despite its widespread use in industrial gamma radiography, a Se brachytherapy source has yet to be manufactured.
Purpose: A novel Se-based source design with a vanadium diselenide core, titled the SeCure source, was proposed.
ACS Appl Mater Interfaces
September 2025
Faculty of Chemistry, Jagiellonian University, Gronostajowa 2, Kraków 30-387, Poland.
The multifunctional systems presented here introduce an innovative and deeply thought-out approach to the more effective and safer use of temozolomide (TMZ) in treating glioma. The developed hydrogel-based flakes were designed to address the issues of local GBL therapy, bacterial neuroinfections, and the bleeding control needed during tumor resection. The materials obtained comprise TMZ and vancomycin (VANC) loaded into cyclodextrin/polymeric capsules and embedded into gelatin/hyaluronic acid/chitosan-based hydrogel films cross-linked with genipin.
View Article and Find Full Text PDFFood Res Int
November 2025
Hainan University-HSF/LWL Collaborative Innovation Laboratory, College of Food Sciences & Engineering, Hainan University, 58 People Road, Haikou 570228, China; Haikou Key Laboratory of Special Foods, Haikou, Hainan 570228, China.
In this study, we explored the application of lactoferrin-(-)-epigallocatechin-3-gallate (LF-EGCG) complex with rapeseed, soybean, walnut, peanut and sesame oil for the preparation of Pickering emulsions and its spray-dried microcapsules. Spectroscopy and molecular docking revealed that LF-EGCG binds via hydrogen bonds, hydrophobic interactions, and van der Waals forces. Structural analysis demonstrated that 0.
View Article and Find Full Text PDFProg Mol Biol Transl Sci
September 2025
School of Forensic Science, National Forensic Sciences University, Gandhinagar, Gujarat, India.
Ingestible biosensors are a mix of advanced biomedical engineering, digital health and precision pharmacotherapy. These miniaturised electronic devices are encapsulated in biocompatible materials, which operate within gastrointestinal (GI) tract. This enables real-time monitoring of pharmacological and physiological parameters.
View Article and Find Full Text PDFmBio
September 2025
Flinders Accelerator for Microbiome Exploration, College of Science and Engineering, Flinders University, Adelaide, South Australia, Australia.
Multidrug-resistant (MDR) and extensively drug-resistant (XDR) ESKAPE pathogens pose a significant global health threat due to their ability to evade antibiotics through intrinsic and acquired mechanisms. These bacteria, including , , , , , and species, evade antibiotics through intrinsic and adaptive mechanisms. Common strategies include capsule formation, biofilm, β-lactamase production, and efflux activity.
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