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http://dx.doi.org/10.1056/NEJMp1905589 | DOI Listing |
Hepatology
September 2025
Department of Pathology, Department of Molecular Biology, Moores Cancer Center, University of California San Diego, La Jolla, CA 92037, USA.
Background And Aims: So far, there is no effective mechanism-based therapeutic agent tailored for liver tumors. Immune checkpoint inhibitors (ICIs) have demonstrated limited efficacy in liver cancer, often associated with severe adverse effects. Although poly-inosinic:cytidylic acid (polyIC) has shown an adjuvant effect when combined with anti-PD-L1 antibody (αPD-L1) in treating liver tumors in animal models, its systemic toxicity limits its clinical utility.
View Article and Find Full Text PDFFront Pharmacol
August 2025
State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, Beijing, China.
Diabetes mellitus is a metabolic disease with a high global prevalence, which affects blood vessels throughout the entire body. As the disease progresses, it often leads to complications, including diabetic retinopathy and nephropathy. Currently, in addition to traditional cellular and animal models, more and more organoid models have been used in the study of diabetes and have broad application prospects in the field of pharmacological research.
View Article and Find Full Text PDFCurr Drug Discov Technol
September 2025
Centre for Research Impact & Outcome, Chitkara College of Pharmacy, Chitkara University, Rajpura, 140401, Punjab, India.
Ethnopharmacology is the study of traditional medicinal knowledge and its application in modern drug discovery. It combines ethnobotanical insights with scientific research to identify bio-active compounds with therapeutic potential. Sustainable agriculture refers to farming practices that maintain ecological balance, support biodiversity, and ensure the long-term availability of resources.
View Article and Find Full Text PDFEnviron Res
September 2025
National Key Laboratory of Agricultural Microbiology, College of Life Science and Technology, National Engineering Research Center of Microbial Pesticides, Huazhong Agricultural University, Wuhan 430070, PR China; Hubei Hongshan Laboratory, Wuhan 430070, Hubei, China. Electronic address: cmm114@mail
Black soldier fly (BSF) organic fertilizer is known to enhance soil fertility and promote plant growth. However, its effects on soil carbon (C) and nitrogen (N) cycling remains unclear. In this study, we established a BSF chicken manure bioconversion system to produce BSF organic fertilizer and investigate its impacts on soil C and N cycling, as well as microbial ecological networks through metagenomic analysis.
View Article and Find Full Text PDFBiosci Biotechnol Biochem
September 2025
Research Institute for Sustainable Chemistry, National Institute of Advanced Industrial Science and Technology (AIST), Kagamiyama, Higashi-Hiroshima, Hiroshima, Japan.
Lignocellulosic biomass is a carbon-neutral resource crucial to advancing a bio-based economy. The filamentous fungus Talaromyces cellulolyticus demonstrates superior biomass saccharification efficiency compared to conventional enzyme-producing fungi, making it a promising host for enzymatic biomass conversion. To enable molecular studies, we developed a robust genetic transformation system for T.
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