Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
A systematic multimolecule drug design procedure is proposed for promoting hepatogenesis and liver regeneration. Genome-wide microarray data including three hepatic conditions are obtained from the GEO database (GSE15238). System modeling and big data mining methods are used to construct real genome-wide genetic-and-epigenetic networks (GWGENs). Then, we extracted the core GWGENs by applying principal network projection on real GWGENs of normal, developing and regenerating livers, respectively. After that, we investigated the significant signal pathways and epigenetic modifications in the core GWGENs to identify potential biomarkers as drug targets. A multimolecule drug consisting of sulmazole, clofibrate, colchicine, furazolidone, nadolol, eticlopride and felbinac is proposed to target on novel biomarkers for promoting hepatogenesis and liver regeneration.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.2217/rme-2018-0058 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Thirty years of SPM-BrainMap synergy: making and mining coordinate-based literature.
Cereb Cortex
August 2025
Research Imaging Institute, University of Texas Health Science Center at San Antonio, 8403 Floyd Curl Drive, San Antonio, TX 78229, United States.
Statistical Parametric Mapping (SPM) adheres to rigorous methodological standards, including: spatial normalization, inter-subject averaging, voxel-wise contrasts, and coordinate reporting. This rigor ensures that a thematically diverse literature is amenable to meta-analysis. BrainMap is a community database (www.
View Article and Find Full Text PDFWhat are we missing? What are we assuming? The need to foster feature discovery tools to improve statistical models.
Cereb Cortex
August 2025
Section on Functional Imaging Methods & Functional MRI Core Facility, National Institute of Mental Health, 10 Center Drive, Rm 1D80, Bethesda, MD 20892, United States.
Statistical Parametric Mapping (SPM) has been profoundly influential to neuroimaging as it has fostered rigorous, statistically grounded structure for model-based inferences that have led to mechanistic insights about the human brain over the past 30 years. The statistical constructs shared with the world through SPM have been instrumental for deriving meaning from neuroimaging data; however, they require simplifying assumptions which can provide results that, while statistically sound, may not accurately reflect the mechanisms of brain function. A platform that fosters the exploration of the rich and varying neuronal and physiologic underpinnings of the measured signals and their associations to behavior and physiologic measures needs a different set of tools.
View Article and Find Full Text PDFGlobal, regional, and national burden of ovarian cancer, 1990-2021, and projections to 2050: a cross-sectional analysis of the global burden of disease study 2021.
Int J Surg
September 2025
Department of Gynecology, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, Hainan, China.
Background: Ovarian cancer remains the most lethal gynecological cancer, with fewer than 50% of patients surviving more than five years after diagnosis. This study aimed to analyze the global epidemiological trends of ovarian cancer from 1990 to 2021 and also project its prevalence to 2050, providing insights into these evolving patterns and helping health policymakers use healthcare resources more effectively.
Methods: This study comprehensively analyzes the original data related to ovarian cancer from the GBD 2021 database, employing a variety of methods including descriptive analysis, correlation analysis, age-period-cohort (APC) analysis, decomposition analysis, predictive analysis, frontier analysis, and health inequality analysis.
The composition, influencing factors, and physiological functions of bifidobacteria in the infant gut: a review.
Food Funct
September 2025
College of Food Science, Southwest University, Chongqing, 400715, China.
Bifidobacteria are naturally found in the human gut and quickly establish dominance shortly after birth, playing a crucial role in the development and stability of the infant gut microbiota. A growing body of research suggests that host and environmental factors shape the colonization and the relative abundance of bifidobacteria in the infant gut during early life. Understanding the factors that influence bifidobacterial colonization and maintaining normal colonization levels are keys to ensuring gut health.
View Article and Find Full Text PDFTransformations in plasma metabolic profiles of patients with major depression disorder during treatment.
Metab Brain Dis
September 2025
Department of Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277, Jiefang Avenue, Wuhan, Hubei, 430022, China.
Major depression disorder (MDD) is a mental condition that significantly threatens both physical and psychological health. This study aimed to discern variances in plasma metabolic profiles between MDD sufferers and healthy counterparts. Additionally, we tracked the hospitalization journey of MDD patients to investigate the normalization of metabolic irregularities through conventional treatment in the form of self-control.
View Article and Find Full Text PDF