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Article Abstract
Background: Evidence on whether functional surgery is not inferior to amputation for the treatment of in situ or minimally invasive (Breslow thickness ≤0.5 mm) nail melanoma is limited.
Objective: To investigate the difference in local recurrence between the 2 interventions for in situ or minimally invasive nail melanoma using available published studies.
Methods: We performed systematic search on PubMed, Embase, Cochrane Library, trial registers, and grey literature databases from inception to June 28, 2018. We included observational studies with at least 5 patients with in situ or minimally invasive nail melanoma. Main outcome was local recurrence.
Results: The odds ratio synthesized from 5 studies including 109 patients (88 functional operations and 21 amputations) was 1.57 (95% confidence interval, 0.31-8.00).
Limitations: Small sample size and possible interstudy heterogeneity.
Conclusions: Our meta-analysis revealed no difference in local recurrence between the 2 interventions. Considering the functional deficit after amputation, conservative surgery should be the treatment of choice for in situ or minimally invasive nail melanoma.
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| http://dx.doi.org/10.1016/j.jaad.2019.06.012 | DOI Listing |
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