Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
The repair of large bone defects remains a huge challenge for bone regenerative medicine. To meet this challenge, a number of bone substitutes have been developed over recent years to overcome the drawbacks of traditional autograft and allograft therapies. Thus, the improvement of the osteoinductive ability of these substitutes has become a major focus for research in the field of bone tissue engineering. It has been reported that some metallic ions play an important role in bone metabolism in the human body, and that bone repair could be enhanced by incorporating these ions into bone substitutes. Moreover, it is well documented that ions released from these substitutes such as magnesium, zinc, and strontium can increase the osteogenic and angiogenic properties of bone repair scaffolds. However, the mechanisms of action of these ions on cellular bioactivity are currently unclear. Therefore, in the present article, we highlight the recent use of bioactive ions in bone tissue engineering and discuss the effects of these ions on osteogenesis and neovascularisation.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.3290/j.cjdr.a42513 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Analysis of the toxicity and mechanisms of osteoporosis caused by cigarette toxicants using network toxicology and molecular docking techniques.
Sci Total Environ
September 2025
Department of Orthopedics and Traumatology, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, Sichuan Province, China. Electronic address:
The objective of this research was to use a network toxicology approach to examine the possible toxicity of the cigarette toxicants nicotine and coal tar that cause osteoporosis (OP) as well as its molecular processes. We determined the primary chemical structures and 128 targets of action of tar and nicotine using the Swiss Target Prediction, NP-MRD, and PubChem databases. We discovered that genes including DNAJB1, CCDC8, LINC00888, ATP6V1G1, MPV17L2, PPCS, and TACC1 had a disease prognostic guiding value by LASSO analysis and differential analysis of GEO microarray data.
View Article and Find Full Text PDFPreparation, characterization, and antioxidant activity of bovine bone peptide-calcium chelate against oxidative stress-induced injury in Caco-2 cells.
Bioorg Chem
September 2025
Key Innovation Laboratory for Deep and Intensive Processing of Yanbian High Quality Beef (Co-construction by Ministry and Province), Ministry of Agriculture and Rural Affairs, Yanbian University, Yanji 133002, PR China; Department of Food Science and Technology, College of Agricultural, Yanbian Univ
In this study, bovine peptide‑calcium chelates (BBP-Ca) were prepared via enzymatic hydrolysis to generate peptides and fermentation to obtain soluble calcium ions, which were then chelated together. The structural characteristics of BBP-Ca were comprehensively analyzed using FTIR, SEM, and UV spectroscopy. Additionally, its antioxidant capacity was evaluated by examining its protective effects against oxidative stress-induced damage in Caco-2 cells.
View Article and Find Full Text PDFBorate-Ion-Stimulated Macrophages Promote Osteogenic Differentiation of Mesenchymal Stem Cells.
Adv Healthc Mater
September 2025
Graduate School of Engineering, Nagoya Institute of Technology, Gokiso-cho, Showa-ku, Nagoya, 466-8555, Japan.
Immune cells, such as macrophages, stimulated by several types of inorganic ions released from bioactive glasses secrete cytokines that promote and inhibit bone formation. In this study, the effects of borate-ion-stimulated mouse macrophages (RAW264) on the osteogenic differentiation of mouse bone marrow-derived mesenchymal stem cells (KUSA-A1) are investigated. KUSA-A1 is cultured with a borate-ion-containing medium and RAW264-conditioned medium, which contained the secretome released from boron-stimulated RAW264, and its osteogenic differentiation is evaluated.
View Article and Find Full Text PDFEnhanced rotator cuff tendon-bone interface regeneration with injectable manganese-based mesoporous silica nanoparticle-loaded dual crosslinked hydrogels.
Front Bioeng Biotechnol
August 2025
Department of Sports Medicine, The First Affiliated Hospital, Guangdong Provincial Key Laboratory of Speed Capability, The Guangzhou Key Laboratory of Precision Orthopedics and Regenerative Medicine, Jinan University, Guangzhou, Guangdong, China.
Introduction: During the healing process, the functional gradient attachment of the rotator cuff (RC) tendon-bone interface fails to regenerate, which severely impedes load transfer and stress dissipation, thereby increasing the risk of retears. As a result, the treatment of rotator cuff tears remains a significant clinical challenge.
Methods: In this study, a dual-crosslinked hyaluronic acid/polyethylene glycol (HA/PEG) hydrogel scaffold was synthesized using hyaluronic acid and polyethylene glycol as base materials.
Preparation of Bifunctional Orthosilicophosphate MgO-CaO-ZnO-PO-SiO Glasses: in vitro Evaluation of Antibacterial Activity and Osteoblast Gene Expression Behavior.
Adv Healthc Mater
September 2025
Division of Advanced Ceramics, Graduate School of Engineering, Nagoya Institute of Technology, Nagoya, 466-8555, Japan.
Phosphate and phosphate invert glasses contain various elements, with a wide range of compositions. Recently, our group reported orthosilicophosphate glasses (SPGs) and the glass network structure composed of orthophosphates and orthosilicates crosslinked by cations. ZnO is an intermediate oxide that improves the chemical durability of glass.
View Article and Find Full Text PDF