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Article Abstract
Bicyclic ether scaffolds are found in a variety of natural products and are of interest in probe and drug discovery. A palladium-catalyzed cascade reaction has been developed to provide efficient access to these scaffolds from readily available linear diene-diol substrates. A Pd redox-relay process is used strategically to transmit reactivity between an initial oxypalladative cyclization and a subsequent π-allyl-Pd cyclization at remote sites. The reaction affords a variety of bicyclic ether scaffolds with complete diastereoselectivity for cis-ring fusion.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6601619 | PMC |
| http://dx.doi.org/10.1039/c9cc03775f | DOI Listing |
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