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Objectives: The advent of hybrid electro-acoustic implants requires precise positioning of the electrode-array (EA) within the cochlea. The cochlea size, that is, the length of the cochlear scala tympani, is often indirectly estimated from distance A by Escudé's method. This technique has been confirmed by anatomical studies, in a bunch of cadaveric specimens, but it is not yet widely established in the field of computed tomography (CT). We compared cochlear duct length obtained by Escudé's method to those directly acquired on CT images.
Materials And Methods: The lengths of cochlear scala tympani were directly measured on CT scans by contouring the external cochlear wall (contouring technique-CoT). In fifteen patients implanted with a straight EA, the length of the EA and the measured length of the cochlea by the CoT were compared, to check the reliability of the CoT. Then, in 200 CT-scans, the length of the cochlear duct was measured by the CoT then compared to Escudé's method.
Results: In the 200 CT-scans which served for cochlear length measurements, a significant variability between the cochleae were observed, as expected. At 360°, the correlation between the measurements of the length of the cochlear scala tympani between the two techniques differed, with a difference of 0.2 ± 0.7 mm at 360° (extreme: 2 mm; p < 0.001) and 2.2 ± 1.2 mm at 540° (extreme: 5.6 mm; p < 0.001).
Conclusion: The CoT can predict with accuracy the length of EA-insertion depth, more precisely than estimation methods such as Escudé's.
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http://dx.doi.org/10.1007/s00405-019-05432-6 | DOI Listing |
Curr Opin Otolaryngol Head Neck Surg
October 2025
Cambridge University Hospitals, NHS Trust.
Purpose Of Review: Drug delivery to the cochlea has been hampered by the very mechanisms that exist to protect its delicate neurosensory epithelium from pathogens. The blood-brain barrier restricts the distribution of systemic therapies, while local administration is constrained by basal to apical gradients. As we progress towards restorative and regenerative therapies, precise delivery of therapeutics to their target site is required.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
August 2025
Department of Otolaryngology Head and Neck Surgery, Jiangsu Provincial Key Medical Discipline (Laboratory), Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing 210008, China.
Hearing loss (HL) in patients with systemic lupus erythematosus (SLE) has been widely reported, though the underlying mechanisms remain unclear. In this study, we demonstrate significant HL in an imiquimod-induced mouse model of SLE, accompanied by blood-labyrinth barrier (BLB) damage in the stria vascularis (SV). We found that cytotoxic CD8 T lymphocytes and natural killer cells mediate BLB disruption, with granzyme b (Gzmb) acting as the primary factor inducing cell death of the cochlear capillary endothelial cells.
View Article and Find Full Text PDFGene Expr Patterns
August 2025
Department of Otolaryngology, Head and Neck Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
CWC27 is a member of cyclophilin-type peptidyl-prolyl cis-trans isomerase family and takes part in the pre-mRNA splicing. The mutation of its gene, Cwc27, has been verified to be related to cancer, craniofacial and skeletal anomalies, retinal degeneration, and hearing loss. However, expression pattern of Cwc27 in the development of inner ear has not been fully understood.
View Article and Find Full Text PDFJ Laryngol Otol
August 2025
Department of Ophthalmology, All India Institute of Medical Sciences, Rishikesh, India.
Objectives: To compare two high-resolution computerised tomography based pre-surgical planning software in measuring the cochlear dimensions, which can aid in designing/choosing customised cochlear implant electrodes.
Methods: A cross-sectional-observational study was conducted in a tertiary care centre using high-resolution computerised tomography-supported software Otoplan and curved multi-planar reconstruction to find cochlear duct length's maximum and minimum width/diameter and height in 110 ears (55 subjects). Measurements and the time taken by both techniques were compared.
Otolaryngol Head Neck Surg
August 2025
APHP, Sorbonne Université, GHU Pitié-Salpêtrière, Service d'ORL et de chirurgie cervico-faciale, UF Implants Auditifs, Paris, France.
Objective: The study aimed to describe the auditory phenotype of patients with bilateral enlarged vestibular aqueduct, including benefits of cochlear implantation, and to look for genotype-phenotype correlation.
Study Design: Retrospective single-center study.
Setting: Tertiary adult reference center.