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Effects of sugammadex on heart rate variability in anesthetized male rats.
Physiol Rep
August 2025
Department of Dental Anesthesiology, Tokushima University Hospital, Tokushima, Japan.
The administration of sugammadex has been associated with bradycardia and rarely asystole; however, the underlying mechanisms remain unclear. We examined heart rate variability (HRV) as an index of autonomic nervous system activity and investigated the effects of sugammadex on HRV in α-chloralose and urethane anesthetized male rats. In protocol 1, we examined the effect of intravenous administration of sugammadex (10 mg/kg) alone.
View Article and Find Full Text PDFRational Utilization of Sugammadex Through Quantitative Twitch Monitoring: A Process Improvement Project at a Large Academic Medical Center.
Cureus
June 2025
Anesthesiology and Pain Medicine, University of California Davis School of Medicine, Sacramento, USA.
Background Sugammadex rapidly became the standard of care for neuromuscular blockade reversal at our institution, leading to a substantial increase in pharmacy costs. We hypothesized that administering sugammadex in 75 mg aliquots, rather than 200 mg vials, would improve adherence to FDA dosing guidelines, reduce costs, and promote greater use of quantitative neuromuscular monitoring. Methods This retrospective study analyzed a departmental process improvement initiative.
View Article and Find Full Text PDFAnesthesia information system-assisted detection and effective management of sugammadex-induced anaphylaxis: a case report.
BMC Anesthesiol
July 2025
Department of Anesthesiology, Critical Care and Pain Medicine, NHO Kure Medical Center and Chugoku Cancer Center, 3-1 Aoyama-cho, Kure, 734-0023, Japan.
Background: Sugammadex, a neuromuscular blockade reversal agent, has a reported incidence of severe anaphylaxis of approximately 0.005% in Japan, typically occurring within 5 min of administration. However, detailed case reports describing the full clinical course and associated changes in monitoring parameters—such as vital signs, capnographic waveforms, and airway pressure—remain limited.
View Article and Find Full Text PDFEffects of Sugammadex and Rocuronium on the Electro-mechanical Activity of Cardiac Myocytes.
Korean J Anesthesiol
June 2025
Department of Biophysics, Faculty of Medicine, Okan University, Istanbul, Turkey.
Background: Sugammadex reverses the effects of steroidal neuromuscular-blocking agents, such as rocuronium, by encapsulating these agents. Its cardiovascular adverse effects include QTc prolongation, hypotension, bradycardia, atrioventricular block, atrial fibrillation, and asystole. Additionally, rocuronium has cardiac side effects, such as bradycardia, hypotension, cardiac arrest, circulatory collapse, and ventricular fibrillation.
View Article and Find Full Text PDFReversing rocuronium-induced neuromuscular block by sugammadex: New safety horizon for Indian population.
Natl J Maxillofac Surg
April 2025
Department of Anaesthesiology and Critical Care, Pt B D Sharma, PGIMS @ University of Health Sciences, Rohtak, Haryana, India.
Background & Aim: The study compared the efficacy of neostigmine and sugammadex in reversing rocuronium-induced neuromuscular blockade in patients undergoing surgery. The research aims to understand the drugs' benefits of safe reversal and impact in the diverse Indian population due to genetic, ethnic, lifestyle, and healthcare infrastructure differences.
Methods: The prospective randomized double-blind study was conducted in 40 patients of either sex, aged 18-60 years, belonging to the American Society of Anesthesiologists physical status I-II scheduled for surgery under general anaesthesia requiring tracheal intubation.