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Obesity is a risk factor for many health issues, as are metabolic abnormalities. However, few studies have addressed the associations between obesity/metabolic risk phenotypes and dietary macronutrient intakes (carbohydrate, protein, and fat). Therefore, this study examined the associations between macronutrient intakes and obesity/metabolic risk phenotypes in a Korean population. We used data from the Korean National Health and Nutrition Examination Survey, a cross-sectional survey of Korean civilians, conducted in 2014 and 2016, and data on a total of 7374 participants were analyzed. Macronutrient intakes were defined as the proportions of energy derived from carbohydrate, protein, and fat. Those exhibiting obesity/metabolic risk phenotypes (or not) were divided into four groups: normal weight without metabolic abnormalities; obese without metabolic abnormalities; normal weight with metabolic abnormalities; and obese with metabolic abnormalities. After adjusting for age, smoking status, alcohol consumption, extent of physical activity, household income, and daily fiber intake, no association was found between the proportions of carbohydrate, protein, or fat intakes and obesity/metabolic risk phenotypes except for a positive association between metabolically healthy but obese status and low protein intake in females. Further studies are required to evaluate the effects of macronutrient intakes on obesity/metabolic risk phenotypes and associated health outcomes.
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http://dx.doi.org/10.3390/nu11030628 | DOI Listing |
J Affect Disord
August 2025
Tianjin Key Laboratory of Environment, Nutrition and Public Health, Center for International Collaborative Research on Environment, Nutrition and Public Health, Tianjin Medical University, Tianjin, China; Department of Occupational and Environmental Health, School of Public Health, Tianjin Medical U
Background: Metabolically healthy obesity (MHO) has been linked to an increased risk of cardiovascular disease, but its link to neurological and mental health remains unclear. This cohort study explored associations between metabolic-obesity phenotypes and multiple brain-related disorders.
Methods: This population-based prospective cohort study included 318,103 UK Biobank participants with a median follow-up of 13.
Background: Gout, a metabolic disorder driven by urate crystal deposition, has been understudied in adolescents, particularly in East Asia and China, where rising incidence aligns with rapid dietary and economic shifts. This study assessed the global, East Asian, and Chinese burden of adolescent gout from 1990 to 2021 and projected trends to 2050.
Methods: Using Global Burden of Disease (GBD) 2021 data, we analyzed incidence, prevalence, and disability-adjusted life years (DALYs) among adolescents aged 10-19 years.
J Hepatol
August 2025
Department of Medicine, Duke University, Durham, NC 27705. Electronic address:
Obesity, metabolic syndrome, and aging are major contributors to the rising global burden of chronic liver diseases. Among these, aging remains an often underrecognized driver that intersects with other metabolic and environmental insults to exacerbate liver dysfunction. Cellular senescence, a key hallmark of aging, is increasingly implicated as a central mechanism linking these risk factors to liver pathophysiology.
View Article and Find Full Text PDFBiomedicines
August 2025
Department of Pediatric Diabetes, Clinical Auxology and Obesity, Poznan University of Medical Sciences, 60-572 Poznan, Poland.
Maternal health has a profound impact on fetal development, influencing the risk of pediatric endocrine disorders both directly and indirectly through various biological and environmental mechanisms. Throughout pregnancy, several endocrine disorders can arise or be exacerbated due to the physiological changes that occur. An in-depth review of articles with evidence-based research discussing the significant effects of maternal endocrinopathies and endocrine disruptors on fetal development and infant health was conducted in this review paper.
View Article and Find Full Text PDFJAMA Netw Open
August 2025
Pennington Biomedical Research Center, Baton Rouge, Louisiana.
Importance: Prenatal intensive behavioral therapy (IBT) interventions that promote adequate gestational weight gain (GWG) have had variable and mostly modest effects on clinically relevant maternal and infant outcomes. It is unknown whether different maternal obesity metabolic phenotypes underlie the heterogeneity in response.
Objective: To examine GWG, adverse perinatal outcomes, substrate changes, and differential changes in each in a prenatal IBT intervention conducted among pregnant individuals with 2 identified obesity phenotypes.