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The article Transcriptomics of manually isolated Amborella trichopoda egg apparatus cells, written by María Flores-Tornero, Sebastian Proost, Marek Mutwil, Charles P. Scutt, Thomas Dresselhaus, Stefanie Sprunck, was originally published electronically on the publisher's internet portal (currently SpringerLink) on 1 February 2019 without open access.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6500505 | PMC |
http://dx.doi.org/10.1007/s00497-019-00367-8 | DOI Listing |
J Assoc Res Otolaryngol
September 2025
Department of Anesthesiology, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.
Purpose: The mammalian cochlea has two types of low abundance and highly specialized inner (IHC) and outer (OHC) mechanosensory hair cells. Their malfunction or death is a common cause of congenital and acquired deafness. IHCs and OHCs exhibit different transcriptomes during development.
View Article and Find Full Text PDFbioRxiv
August 2025
Department of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Probe-based hybridization spatial transcriptomics has emerged as a state-of-the-art for neuroscience research. Accurate segmentation of neurons and non-neuronal cells, a critical step for downstream analysis, remains a big challenge. Using human sensory ganglia neurons as an example, we systematically explore this problem.
View Article and Find Full Text PDFJ Biosci
September 2025
Department of Molecular Biology and Biotechnology, Tezpur University, Tezpur 784028, India.
Plants, being sessile organisms, are continually exposed to diverse combinations of biotic and abiotic stresses in their natural habitats. Combined stresses are considered significant threats to plants, particularly in the context of today's climate change. Despite the vast amount of data generated by OMICS experiments, information remains widely dispersed and inaccessible within the literature.
View Article and Find Full Text PDFAnal Chem
September 2025
Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, Indiana 47907, United States.
Lipidomic profiling generates vast datasets, making manual annotation and trend interpretation complex and time-intensive. The structural and chemical diversity of the lipidome further complicates the analysis. While existing tools support targeted lipid identification, they often lack automated workflows and seamless integration with statistical and bioinformatics tools.
View Article and Find Full Text PDFJ Mol Biol
August 2025
Department of Cellular and Genetic Medicine, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China. Electronic address:
The complexity of the tumor microenvironment (TME) makes cancer therapy challenging. Multi-targeting strategies often exhibit superior clinical benefits and dominate ongoing cancer clinical trials. However, existing multi-targeting strategies largely rely on empirical approaches.
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