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http://dx.doi.org/10.1088/1748-605X/aafd84 | DOI Listing |
Pharmaceutics
July 2025
School of Pharmacy, The University of Auckland, Auckland 1010, New Zealand.
For many decades, conventional pharmaceutical excipients have been used to optimize the palatability, processing ability, flowability, and compressibility of various types of medication throughout the production process [...
View Article and Find Full Text PDFTher Deliv
August 2025
Sunway Biofunctional Molecules Discovery Centre (SBMDC), Faculty of Medical and Life Sciences, Sunway University, Sunway, Malaysia.
Front Immunol
August 2025
Department of Neurology, Weihai Municipal Hospital, Cheeloo College of Medicine, Shandong University, Weihai, China.
Background: Myeloid cells, such as resident microglia (MG), infiltrating monocytes (Mo), macrophages (MΦ), and CNS border-associated macrophages (BAM) in the brain, participate in aged brain injury. Aged microglial replacement is protective against brain injury in aged mice; however, whether/how the molecular changes in myeloid cells are affected by this replacement in injured brains remains unclear.
Methods: Aged microglia in mice were eliminated by PLX3397 for 21 consecutive days and repopulated following withdrawal for 21 days; then, intracerebral hemorrhage (ICH) models were constructed.
Signal Transduct Target Ther
June 2025
Institute for Breast Health Medicine, State Key Laboratory of Biotherapy, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
How the host immune system loses its surveillance function during the evolution from normal cell to malignancy is still largely unknown. Here, we investigate the dynamics changes of the pancreatic ductal adenocarcinoma (PDAC) tumor microenvironment by profiling 132,115 single-cell transcriptomes derived from 51 tissues, including healthy pancreatic tissue, non-metastatic PDAC primary tumors, metastatic primary tumors, and patient-matched liver metastases. The cellular proportion, bio-functional, and interaction between each cell type are carefully characterized.
View Article and Find Full Text PDFFront Physiol
May 2025
Department of Chemistry and Molecular Biology, University of Gothenburg, Gothenburg, Sweden.