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Adolescence is a critical period in the development of addictive behaviors. In particular, the age at which adolescents start drinking is not a trivial matter, given the important consequences that it has. However, relatively little is known about what it is that causes them to start drinking at an ever earlier age. The aim of this paper is to collect new empirical data about the implications of an early age of onset and, at the same time, to identify possible associated variables. Furthermore, the mean age of onset of the different substances is updated by expanding the sample frame of the ESTUDES (14-18 years) to incorporate adolescents aged 12 and 13. The results obtained with a sample of 3,419 adolescents from the Autonomous Community of Galicia (M = 14.57 and SD = 1.76) reveal that at 13.4 years of age, the age at which adolescents tend to start drinking is lower than suggested by ESTUDES 2016-2017. In addition, those who start drinking earlier are more likely to use other substances, their rates of high-risk consumption are 3 times higher and they are more involved in potentially dangerous practices. Finally, variables such as risk perception and expectations of use yield very limited explanatory capacity, especially if they are compared with those related to drinking within the family or peer group. The results reinforce the need to delay the age of alcohol onset as one of the strategic objectives of prevention policies.
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http://dx.doi.org/10.20882/adicciones.1266 | DOI Listing |
Appl Radiat Isot
September 2025
Academy of Applied Studies Šabac, Dobropoljska 5, 15000, Šabac, Serbia; Institute of Public Health of Šabac, Jovana Cvijića 1, 15000, Šabac, Serbia; University of Novi Sad, Faculty of Medicine, Hajduk Veljkova 3, 21000, Novi Sad, Serbia.
Drinking water that contains elevated levels of radioactive substances can pose a potential risk for the development of cancer. Therefore, regular monitoring of radioactivity in water intended for human consumption is essential. In this context, a long-term investigation was carried out across 13 sites in the Mačva District (Western Serbia) during the 2010-2020 period.
View Article and Find Full Text PDFAAPS J
September 2025
Unit for Pharmacokinetics and Drug Metabolism, Sahlgrenska Academy, University of Gothenburg, Box 431, 405 30, Gothenburg, Sweden.
Intravenous dosing of L- and D-eflornithine in a racemic mixture is a currently recommended late-stage gambiense human African trypanosomiasis (g-HAT) treatment, either as 14-day monotherapy or in combination with oral nifurtimox for seven days. However, an oral eflornithine treatment against late-stage g-HAT would be preferable. Pharmacokinetics of eflornithine are enantioselective with different oral absorption of the enantiomers.
View Article and Find Full Text PDFPLoS One
September 2025
MRC Lifecourse Epidemiology Centre, University of Southampton, Southampton, United Kingdom.
During adolescence, many young people start to make more independent food purchases. Subsequently, these independent food choices will increasingly contribute to their overall diet quality; little is known, however, about this relationship. This pilot study aimed to examine the role adolescents' independent food purchases play in their diet quality and assess if these relationships vary according to socio-economic status.
View Article and Find Full Text PDFBMC Psychiatry
August 2025
Department of psychiatry, College Health Science, Mekelle University, Mekelle, Ethiopia.
Background: Schizophrenia is one of the most disruptive of neuropsychiatric disorders, affecting around 1% of the world's population. Antipsychotic medications have been the backbone of schizophrenia treatment for the past 50 years. Extrapyramidal side effects of antipsychotic medication are a major problem which is associated with various factors.
View Article and Find Full Text PDFToxics
August 2025
Department of Immunomorphology of Inflammation, Avtsyn Research Institute of Human Morphology of Federal State Budgetary Scientific Institution "Petrovsky National Research Centre of Surgery", 117418 Moscow, Russia.
Environmental pollution with microplastics (MPs) can have a negative impact on human health. Certain findings point to the relationship between MP and the development of inflammatory bowel diseases (IBD). We investigated the effect of MP consumption on the severity of chronic colitis in male C57BL/6 mice.
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