98%
921
2 minutes
20
Recurrent backpropagation and equilibrium propagation are supervised learning algorithms for fixed-point recurrent neural networks, which differ in their second phase. In the first phase, both algorithms converge to a fixed point that corresponds to the configuration where the prediction is made. In the second phase, equilibrium propagation relaxes to another nearby fixed point corresponding to smaller prediction error, whereas recurrent backpropagation uses a side network to compute error derivatives iteratively. In this work, we establish a close connection between these two algorithms. We show that at every moment in the second phase, the temporal derivatives of the neural activities in equilibrium propagation are equal to the error derivatives computed iteratively by recurrent backpropagation in the side network. This work shows that it is not required to have a side network for the computation of error derivatives and supports the hypothesis that in biological neural networks, temporal derivatives of neural activities may code for error signals.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1162/neco_a_01160 | DOI Listing |
Phys Biol
September 2025
CNR-Istituto dei Sistemi Complessi, Via dei Taurini 19, I-00185 Rome, Italy.
Understanding the link between structure and function in proteins is fundamental in molecular biology and proteomics. A central question in this context is whether allostery-where the binding of a molecule at one site affects the activity of a distant site-emerges as a further manifestation of the intricate interplay between structure, function, and intrinsic dynamics. This study explores how allosteric regulation is modified when intrinsic protein dynamics operates under out-of-equilibrium conditions.
View Article and Find Full Text PDFSci Rep
August 2025
Business School, University of Shanghai for Science and Technology, Shanghai, 200093, China.
Rumor spreading has been posing a significant threat to maintain the normal social order. In this paper, we propose a ISDR rumor propagation model on scale-free networks that considers fractional-order and refutation mechanism. we acquire basic reproduction number [Formula: see text] based on the rumor equilibrium point [Formula: see text], which thoroughly characterizes the dynamics of rumor propagation.
View Article and Find Full Text PDFPhys Chem Chem Phys
September 2025
Keck Center for Science and Engineering, Graduate Program in Computational and Data Sciences, Schmid College of Science and Technology, Chapman University, Orange, CA 92866, USA.
The ongoing evolution of SARS-CoV-2 variants has underscored the need to understand not only the structural basis of antibody recognition but also the dynamic and allosteric mechanisms that could be the underlying contributors to their complex broad and escape-resistant neutralization activities. In this study, we employed a multi-scale approach integrating structural analysis, hierarchical molecular simulations, mutational scanning and network-based allosteric modeling to dissect how class 4 antibodies (represented by S2X35, 25F9, and SA55) and class 5 antibodies (represented by S2H97, WRAIR-2063 and WRAIR-2134) can modulate conformational behavior, binding energetics, allosteric interactions and immune escape patterns of the SARS-CoV-2 spike protein. Using hierarchical simulations of the antibody complexes with the spike protein and ensemble-based mutational scanning of binding interactions we showed that these antibodies through targeting conserved cryptic sites can exert allosteric effects that influence global conformational dynamics in the RBD functional regions.
View Article and Find Full Text PDFPlants (Basel)
July 2025
College of Mechanical and Electrical Engineering, Gansu Agricultural University, Lanzhou 730070, China.
To address the challenges of low recognition accuracy and substantial model complexity in crop disease identification models operating in complex field environments, this study proposed a novel hybrid model named ConvTransNet-S, which integrates Convolutional Neural Networks (CNNs) and transformers for crop disease identification tasks. Unlike existing hybrid approaches, ConvTransNet-S uniquely introduces three key innovations: First, a Local Perception Unit (LPU) and Lightweight Multi-Head Self-Attention (LMHSA) modules were introduced to synergistically enhance the extraction of fine-grained plant disease details and model global dependency relationships, respectively. Second, an Inverted Residual Feed-Forward Network (IRFFN) was employed to optimize the feature propagation path, thereby enhancing the model's robustness against interferences such as lighting variations and leaf occlusions.
View Article and Find Full Text PDFSci Adv
August 2025
Department of Physics, University of Konstanz, 78464 Konstanz, Germany.
In topology, averaging over local geometrical details reveals robust global features. These are crucial in physics for understanding quantized bulk transport and exotic boundary effects of linear wave propagation in (meta-)materials. Beyond linear Hamiltonian systems, topological physics strives to characterize open (non-Hermitian) and interacting systems.
View Article and Find Full Text PDF