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Article Abstract
Objective: The extract of different species of has been successfully used as a remedy for treatment of cutaneous leishmaniasis. The aim of this study was to assess the leishmanicidal effect of () extract.
Materials And Methods: Ethanolic percolated and methanolic Soxhlet extract of on promastigotes of at different concentrations of extracts, one positive control group and one negative control group as well as 1 solvent control were prepared and placed in 24-well plates that contained 40,000 parasites/well. Afterwards, plates were incubated at 25 ˚C for six days and number of parasites in each well were determined on days 2, 4 and 6 of the experiment.
Results: Both percolated and Soxhlet extracts in methanol and DMSO solvents had significant effects (equal to that of amphotericin B) on promastigote form of parasite at the concentration of 1 mg/ml. At lower concentrations, the extracts of had favorable leishmanicidal activity and killed promastigotes dose-dependently.
Conclusion: Our results support the possibility of extracts application as an anti-leishmanial agent with similar effects to amphotericin B.
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