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Polymer microfluidic devices are used for many purposes such as microarrays and biochips. The key tool for manufacturing these chips in bulk is an appropriate mold. However, the popular material for making molds is nickel or nickel alloys, which have low stiffness and wear out easily. Zr-based metallic glass is a promising material for micro- or nanomolds because it has good mechanical properties and can be easily formed with high precision. In this paper, Zr-based metallic glass is proposed for use as micromold insert to make poly-(methyl methacrylate) (PMMA) microfluidic devices. Our experiments show that they have good feature integrity and replication quality. Microchannels we fabricated using these replicas did not leak and had good flow performance. Zr-based metallic glass can greatly ease the manufacture of plastic microfluidic devices for research and commercial applications.
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http://dx.doi.org/10.1007/s10544-018-0342-0 | DOI Listing |
Lab Chip
September 2025
Department of Engineering Design, Indian Institute of Technology Madras, India.
Microfluidic devices offer more accurate fluid flow control and lower reagent use for uniform nanoparticle synthesis than batch synthesis. Here, we propose a microfluidic device that synthesizes uniform iron oxide nanoparticles (IONPs) for highly efficient intracellular delivery. The 3D-printed device was fabricated, comprising two inlets in the T-shaped channel with an inner diameter of 2 mm, followed by a helical mixing channel with a single outlet.
View Article and Find Full Text PDFACS Biomater Sci Eng
September 2025
Chemical Engineering, University of Waterloo, Waterloo, Ontario N2L 3G1, Canada.
Patient-derived tumor organoids (PDTOs) are promising 3D disease models for developing personalized treatment methods. However, conventional technologies for making PDTOs have limitations such as batch-to-batch variation and low throughput. Droplet microfluidics (DM), which utilizes uniform droplets generated in microchannels, has demonstrated potential for creating organoids due to its high-throughput and controllable parameters.
View Article and Find Full Text PDFAnal Chim Acta
November 2025
Marine Engineering College, Dalian Maritime University, Dalian, 116026, China. Electronic address:
On-site and accurately detecting, sizing and counting living algae are greatly needed under International Ballast Water Convention, yet still challenging due to the lack of miniatured device. In this paper, a miniatured microscope that has both blue view field and fluorescence field was developed. Dual-view-field with one exciting light is achieved by using a beam splitter to direct the light into two mini cameras.
View Article and Find Full Text PDFSoft Matter
September 2025
Department of Mechanical Engineering, Clemson University, Clemson, SC 29634-0905, USA.
Pores scale flows through contractions and expansions are relevant in geoengineering, microfluidics and material processing These flows experience shearing and extensional kinematics near constrictions, where polymer solutions may demonstrate instabilities that arise from the fluid's nonlinear rheological characteristics even in creeping flows. The relative effect of shearing and extension can be controlled by the flow geometry. Following our earlier reports on the constriction length (M.
View Article and Find Full Text PDFMetal nanoparticles (MNPs) have emerged as vital components in nanotechnology due to their unique ability to concentrate light at the nanoscale. This property makes them especially valuable in biosensing applications, where high sensitivity is essential. At the same time, cellulose-based materials like paper offer an affordable, widely available, and versatile platform, making them ideal for the development of paper-based microfluidic analytical devices (μPADs).
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