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Purpose: To investigate the primary causes of visual impairment and blindness in rural China.
Design: Population-based, cross-sectional study.
Methods: Geographic cluster sampling was used in randomly selecting residents from a rural county/district within 9 provinces in the East Coast, Inland Middle, and West regions of mainland China. Persons aged 50 years or older were enumerated through household visits and invited to examination sites for visual acuity testing and ocular examination. Causes of vision impairment and blindness in 2014 were compared with data from an earlier 2006 survey.
Results: Mild visual impairment (20.4% prevalence) was caused by uncorrected refractive error in two thirds of cases and by cataract in nearly another one fourth; moderate-to-severe visual impairment (10.3% prevalence) was caused by cataract in over onec half of cases and by uncorrected refractive error in another one fifth; blindness (1.66% prevalence) was caused by cataract in approximately one half of cases and in another one fourth by retinal disease. Primary causes of visual impairment and blindness in cataract-operated eyes were uncorrected refractive error, posterior capsule opacity, and retinal disease. From 2006 to 2014, the proportion of visual impairment caused by uncorrected refractive error increased, but rates for unoperated cataract were reduced.
Conclusions: Uncorrected refractive error and unoperated cataract are the 2 primary causes of mild, moderate, and severe visual impairment in rural China, with unoperated cataract and retinal diseases primary causes for blindness. An effective public health strategy to increase service delivery for these causes would lead to substantial reduction in vision impairment and blindness.
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http://dx.doi.org/10.1016/j.ajo.2018.09.011 | DOI Listing |
Ophthalmic Plast Reconstr Surg
September 2025
Department of Ophthalmology, Byers Eye Institute, Stanford University School of Medicine, Palo Alto, California, U.S.A.
Purpose: To evaluate the efficacy and safety of teprotumumab for the treatment of thyroid eye disease in geriatric patients.
Methods: This was a multicenter cohort study of patients aged 75 and older, treated between February 2020 and September 2023 across 10 tertiary institutions. Patients were included if they had moderate-to-severe thyroid eye disease and at least 1 infusion of teprotumumab.
Adv Mater
September 2025
Key Laboratory of Brain-Like Neuromorphic Devices and Systems of Hebei Province, College of Electronic and Information Engineering, Hebei University, Baoding, 071002, China.
Neuromorphic Visual Devices hold considerable promise for integration into neuromorphic vision systems that combine sensing, memory, and computing. This potential arises from their synergistic benefits in optical signal detection and neuro-inspired computational processes. However, current devices face challenges such as insufficient light/dark resistance ratios, mismatched transient photo-response, and volatile retention characteristics, limiting their adaptability to complex artificial vision systems.
View Article and Find Full Text PDFOphthalmic Physiol Opt
September 2025
Division of Occupational Therapy and Physical Therapy, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Purpose: Cerebral Visual Impairment (CVI) is the leading cause of paediatric visual impairment in developed countries. Earlier diagnosis provides access to early intervention, which may improve visual function, functional vision and developmental outcomes. The purpose of this study was to determine the age and timing of CVI diagnosis and the severity of CVI.
View Article and Find Full Text PDFFront Cell Neurosci
August 2025
Stem Cell Research Center, University of California, Irvine, Irvine, CA, United States.
Objective: To assess the safety and tolerability of intravitreal injection of human retinal progenitor cells (RPCs) at multiple dose levels in adults with non-syndromic retinitis pigmentosa (RP).
Design: A prospective, multicenter, open-label, single-arm, Phase I/IIa safety study of RPCs in adults with RP ( = 28). Two patient cohorts were studied: Cohort 1: BCVA no better than 20/200 and no worse than Hand Motions, and Cohort 2: BCVA no better than 20/40 and no worse than 20/200).
IEEE Nanotechnol Mater Devices Conf
October 2024
D. Keith Roper is with Utah State University, Logan, UT 84322 USA.
Nanoparticle labels enable colorimetric point-of-care devices for rapid, low-cost diagnosis and health monitoring. Accurate interpretation of colorimetric assays relies on reliable perception of differences in quantitative color attributes such as hue, chromaticity, and saturation. This study examined interactions between physical factors such as nanoparticle shape, illumination, and sample environment, and biological factors affecting color vision deficit and optical signal processing that influenced perceived color difference.
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