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Article Abstract
A newly fluorescence probe for detection of Serotonin based on a Mn-doped ZnS quantum dots@silica nanoparticle@molecularly imprinted polymers (QDs@SiO@MIPs) was successfully created. QDs@SiO@MIPs were characterized by scanning electron microscope, transmission electron microscope, Fourier transform infrared spectroscopy, UV spectroscopy, X-ray powder diffraction, and fluorescence spectroscopy. A complex was produced between the amino group of QDs@SiO@MIPs and the hydroxyl group of 5-HT when 5-HT rebinding, the energy of the QDs would be transferred to the complex, which led to its fluorescence quenching. The composite material has a high selectivity with an imprinting factor of 5.96. The linear regression equation is F/F = 0.0036Cq-0.0512, with a correlation coefficient of 0.9928 in a liner range from 50 to 500 ng/mL. The limit of detection(LOD) was 0.69 ng/mL. The probe exhibited simple preparation process, high sensitivity, good selectivity, low detection limit, short analysis time and could be applied to detect 5-HT in human serum successfully.
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